Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/- |
Location | 2257609..2258855 | Replicon | chromosome |
Accession | NZ_CP007780 | ||
Organism | Burkholderia cenocepacia strain DWS 37E-2 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | DM40_RS13815 | Protein ID | WP_040140618.1 |
Coordinates | 2258274..2258855 (+) | Length | 194 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | DM40_RS13810 | Protein ID | WP_040141263.1 |
Coordinates | 2257609..2258166 (+) | Length | 186 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DM40_RS31225 | 2253389..2253952 | - | 564 | WP_144245384.1 | hypothetical protein | - |
DM40_RS13795 | 2254223..2254858 | + | 636 | WP_040140612.1 | cysteine hydrolase | - |
DM40_RS13800 | 2254943..2255674 | - | 732 | WP_040140614.1 | ribonuclease T2 | - |
DM40_RS13805 | 2255879..2257282 | - | 1404 | WP_040140616.1 | hypothetical protein | - |
DM40_RS13810 | 2257609..2258166 | + | 558 | WP_040141263.1 | helix-turn-helix domain-containing protein | Antitoxin |
DM40_RS13815 | 2258274..2258855 | + | 582 | WP_040140618.1 | HD domain-containing protein | Toxin |
DM40_RS13820 | 2259111..2260649 | - | 1539 | WP_040140620.1 | MFS transporter | - |
DM40_RS13825 | 2260836..2261771 | + | 936 | WP_040140622.1 | LysR family transcriptional regulator | - |
DM40_RS13830 | 2261814..2262953 | - | 1140 | WP_040140624.1 | enoyl-CoA hydratase/isomerase family protein | - |
DM40_RS13835 | 2262950..2263741 | - | 792 | WP_040140626.1 | enoyl-CoA hydratase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 194 a.a. Molecular weight: 21387.88 Da Isoelectric Point: 4.7410
>T47003 WP_040140618.1 NZ_CP007780:2258274-2258855 [Burkholderia cenocepacia]
MNLDTIHARLDFLRDAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPDVDTTKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSTHERDDLQTLTAGLDRALRDEIVALWDEYEAAVSPEARAAKALDKLETIMQHNQGSNPPDFDYAFNLGY
GRRYTDAAPLFGAIRAIVDADTQRRIDTRDDGA
MNLDTIHARLDFLRDAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPDVDTTKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSTHERDDLQTLTAGLDRALRDEIVALWDEYEAAVSPEARAAKALDKLETIMQHNQGSNPPDFDYAFNLGY
GRRYTDAAPLFGAIRAIVDADTQRRIDTRDDGA
Download Length: 582 bp
>T47003 NZ_CP007780:2258274-2258855 [Burkholderia cenocepacia]
ATGAACCTCGATACGATTCACGCGCGGCTCGATTTCCTGCGCGACGCCGAACGCCTGAAAGACGTGCTTCGCAGTGGCCA
TACGTCGGCCGGGCGCGCTGAAAGCACGGCCGAACACAGCTGGCGGCTATGCCTGATGGCACTCGTGTTTGCCGATGCGC
TACCCGACGTCGACACGACGAAGCTGCTGAAGCTCTGCGTCGTGCACGATCTCGGCGAAGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCATCCTGACAAGAGCACACACGAACGCGACGACCTGCAGACGCTGACAGCCGGACTCGATCG
CGCGCTGCGCGACGAGATCGTCGCACTGTGGGACGAATATGAAGCGGCAGTCTCCCCGGAAGCACGCGCAGCGAAGGCAC
TCGACAAGCTGGAGACGATCATGCAGCACAACCAGGGGAGCAATCCGCCGGATTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCTACACCGACGCGGCGCCGCTGTTCGGCGCGATCCGCGCGATCGTCGATGCGGACACGCAACGCAGGATCGA
TACTCGCGACGACGGCGCGTAA
ATGAACCTCGATACGATTCACGCGCGGCTCGATTTCCTGCGCGACGCCGAACGCCTGAAAGACGTGCTTCGCAGTGGCCA
TACGTCGGCCGGGCGCGCTGAAAGCACGGCCGAACACAGCTGGCGGCTATGCCTGATGGCACTCGTGTTTGCCGATGCGC
TACCCGACGTCGACACGACGAAGCTGCTGAAGCTCTGCGTCGTGCACGATCTCGGCGAAGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCATCCTGACAAGAGCACACACGAACGCGACGACCTGCAGACGCTGACAGCCGGACTCGATCG
CGCGCTGCGCGACGAGATCGTCGCACTGTGGGACGAATATGAAGCGGCAGTCTCCCCGGAAGCACGCGCAGCGAAGGCAC
TCGACAAGCTGGAGACGATCATGCAGCACAACCAGGGGAGCAATCCGCCGGATTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCTACACCGACGCGGCGCCGCTGTTCGGCGCGATCCGCGCGATCGTCGATGCGGACACGCAACGCAGGATCGA
TACTCGCGACGACGGCGCGTAA
Antitoxin
Download Length: 186 a.a. Molecular weight: 20372.46 Da Isoelectric Point: 9.5434
>AT47003 WP_040141263.1 NZ_CP007780:2257609-2258166 [Burkholderia cenocepacia]
MCASPLHTPPLGPQLKRWRTLHRMKQSHAAELFGVAQSTISRWEAGIQQMSDDERAMAERLLAARLDSAGDRALARLIES
SPSRMHLVCDLTHRLLASSPSRAAEFSRPLATLLGTSLWRYASPEIVRMEAALDPLGWRDCAGPPSVEFPTGANASRIVP
IRGSTCRWTRMMLSDGSAARLVETL
MCASPLHTPPLGPQLKRWRTLHRMKQSHAAELFGVAQSTISRWEAGIQQMSDDERAMAERLLAARLDSAGDRALARLIES
SPSRMHLVCDLTHRLLASSPSRAAEFSRPLATLLGTSLWRYASPEIVRMEAALDPLGWRDCAGPPSVEFPTGANASRIVP
IRGSTCRWTRMMLSDGSAARLVETL
Download Length: 558 bp
>AT47003 NZ_CP007780:2257609-2258166 [Burkholderia cenocepacia]
ATGTGCGCGTCACCGCTTCATACTCCGCCGCTCGGCCCGCAACTCAAGCGTTGGCGCACGCTGCATCGCATGAAGCAGAG
TCACGCGGCCGAGTTGTTCGGCGTTGCGCAATCGACGATCTCGCGCTGGGAGGCCGGCATCCAGCAGATGTCCGACGACG
AGCGCGCGATGGCCGAACGGCTGCTTGCCGCGCGTCTCGATTCAGCGGGCGATCGCGCGCTCGCCCGGCTGATCGAGAGC
AGCCCGTCACGCATGCATCTCGTATGCGATCTCACGCACCGTCTGCTCGCCAGTTCGCCATCGCGCGCCGCCGAGTTCTC
GCGGCCGCTGGCGACGTTGCTCGGCACGTCGCTCTGGCGGTACGCGTCGCCGGAAATCGTCCGCATGGAAGCCGCGCTCG
ACCCGCTTGGCTGGCGCGATTGCGCGGGACCGCCGAGCGTCGAATTCCCGACCGGCGCCAATGCGTCGCGCATCGTGCCG
ATCCGCGGCAGCACCTGCCGCTGGACGCGGATGATGCTGTCGGACGGCTCCGCCGCGCGACTCGTCGAAACGCTGTAG
ATGTGCGCGTCACCGCTTCATACTCCGCCGCTCGGCCCGCAACTCAAGCGTTGGCGCACGCTGCATCGCATGAAGCAGAG
TCACGCGGCCGAGTTGTTCGGCGTTGCGCAATCGACGATCTCGCGCTGGGAGGCCGGCATCCAGCAGATGTCCGACGACG
AGCGCGCGATGGCCGAACGGCTGCTTGCCGCGCGTCTCGATTCAGCGGGCGATCGCGCGCTCGCCCGGCTGATCGAGAGC
AGCCCGTCACGCATGCATCTCGTATGCGATCTCACGCACCGTCTGCTCGCCAGTTCGCCATCGCGCGCCGCCGAGTTCTC
GCGGCCGCTGGCGACGTTGCTCGGCACGTCGCTCTGGCGGTACGCGTCGCCGGAAATCGTCCGCATGGAAGCCGCGCTCG
ACCCGCTTGGCTGGCGCGATTGCGCGGGACCGCCGAGCGTCGAATTCCCGACCGGCGCCAATGCGTCGCGCATCGTGCCG
ATCCGCGGCAGCACCTGCCGCTGGACGCGGATGATGCTGTCGGACGGCTCCGCCGCGCGACTCGTCGAAACGCTGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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