Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/-
Location 2257609..2258855 Replicon chromosome
Accession NZ_CP007780
Organism Burkholderia cenocepacia strain DWS 37E-2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DM40_RS13815 Protein ID WP_040140618.1
Coordinates 2258274..2258855 (+) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DM40_RS13810 Protein ID WP_040141263.1
Coordinates 2257609..2258166 (+) Length 186 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM40_RS31225 2253389..2253952 - 564 WP_144245384.1 hypothetical protein -
DM40_RS13795 2254223..2254858 + 636 WP_040140612.1 cysteine hydrolase -
DM40_RS13800 2254943..2255674 - 732 WP_040140614.1 ribonuclease T2 -
DM40_RS13805 2255879..2257282 - 1404 WP_040140616.1 hypothetical protein -
DM40_RS13810 2257609..2258166 + 558 WP_040141263.1 helix-turn-helix domain-containing protein Antitoxin
DM40_RS13815 2258274..2258855 + 582 WP_040140618.1 HD domain-containing protein Toxin
DM40_RS13820 2259111..2260649 - 1539 WP_040140620.1 MFS transporter -
DM40_RS13825 2260836..2261771 + 936 WP_040140622.1 LysR family transcriptional regulator -
DM40_RS13830 2261814..2262953 - 1140 WP_040140624.1 enoyl-CoA hydratase/isomerase family protein -
DM40_RS13835 2262950..2263741 - 792 WP_040140626.1 enoyl-CoA hydratase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(16-169)

Antitoxin

(12-61)


Sequences


Toxin        


Download         Length: 194 a.a.        Molecular weight: 21387.88 Da        Isoelectric Point: 4.7410

>T47003 WP_040140618.1 NZ_CP007780:2258274-2258855 [Burkholderia cenocepacia]
MNLDTIHARLDFLRDAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPDVDTTKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSTHERDDLQTLTAGLDRALRDEIVALWDEYEAAVSPEARAAKALDKLETIMQHNQGSNPPDFDYAFNLGY
GRRYTDAAPLFGAIRAIVDADTQRRIDTRDDGA

Download         Length: 582 bp

>T47003 NZ_CP007780:2258274-2258855 [Burkholderia cenocepacia]
ATGAACCTCGATACGATTCACGCGCGGCTCGATTTCCTGCGCGACGCCGAACGCCTGAAAGACGTGCTTCGCAGTGGCCA
TACGTCGGCCGGGCGCGCTGAAAGCACGGCCGAACACAGCTGGCGGCTATGCCTGATGGCACTCGTGTTTGCCGATGCGC
TACCCGACGTCGACACGACGAAGCTGCTGAAGCTCTGCGTCGTGCACGATCTCGGCGAAGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCATCCTGACAAGAGCACACACGAACGCGACGACCTGCAGACGCTGACAGCCGGACTCGATCG
CGCGCTGCGCGACGAGATCGTCGCACTGTGGGACGAATATGAAGCGGCAGTCTCCCCGGAAGCACGCGCAGCGAAGGCAC
TCGACAAGCTGGAGACGATCATGCAGCACAACCAGGGGAGCAATCCGCCGGATTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCTACACCGACGCGGCGCCGCTGTTCGGCGCGATCCGCGCGATCGTCGATGCGGACACGCAACGCAGGATCGA
TACTCGCGACGACGGCGCGTAA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20372.46 Da        Isoelectric Point: 9.5434

>AT47003 WP_040141263.1 NZ_CP007780:2257609-2258166 [Burkholderia cenocepacia]
MCASPLHTPPLGPQLKRWRTLHRMKQSHAAELFGVAQSTISRWEAGIQQMSDDERAMAERLLAARLDSAGDRALARLIES
SPSRMHLVCDLTHRLLASSPSRAAEFSRPLATLLGTSLWRYASPEIVRMEAALDPLGWRDCAGPPSVEFPTGANASRIVP
IRGSTCRWTRMMLSDGSAARLVETL

Download         Length: 558 bp

>AT47003 NZ_CP007780:2257609-2258166 [Burkholderia cenocepacia]
ATGTGCGCGTCACCGCTTCATACTCCGCCGCTCGGCCCGCAACTCAAGCGTTGGCGCACGCTGCATCGCATGAAGCAGAG
TCACGCGGCCGAGTTGTTCGGCGTTGCGCAATCGACGATCTCGCGCTGGGAGGCCGGCATCCAGCAGATGTCCGACGACG
AGCGCGCGATGGCCGAACGGCTGCTTGCCGCGCGTCTCGATTCAGCGGGCGATCGCGCGCTCGCCCGGCTGATCGAGAGC
AGCCCGTCACGCATGCATCTCGTATGCGATCTCACGCACCGTCTGCTCGCCAGTTCGCCATCGCGCGCCGCCGAGTTCTC
GCGGCCGCTGGCGACGTTGCTCGGCACGTCGCTCTGGCGGTACGCGTCGCCGGAAATCGTCCGCATGGAAGCCGCGCTCG
ACCCGCTTGGCTGGCGCGATTGCGCGGGACCGCCGAGCGTCGAATTCCCGACCGGCGCCAATGCGTCGCGCATCGTGCCG
ATCCGCGGCAGCACCTGCCGCTGGACGCGGATGATGCTGTCGGACGGCTCCGCCGCGCGACTCGTCGAAACGCTGTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References