Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1975722..1977472 Replicon chromosome
Accession NZ_CP007780
Organism Burkholderia cenocepacia strain DWS 37E-2

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag DM40_RS12640 Protein ID WP_040140235.1
Coordinates 1976576..1977472 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag DM40_RS12635 Protein ID WP_040140234.1
Coordinates 1975722..1976579 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM40_RS12615 1970861..1972351 - 1491 WP_040140229.1 aldehyde dehydrogenase -
DM40_RS12620 1972433..1973272 - 840 WP_040140231.1 aspartate dehydrogenase -
DM40_RS12625 1973265..1974935 - 1671 WP_040140232.1 thiamine pyrophosphate-binding protein -
DM40_RS12630 1974928..1975725 - 798 WP_040140233.1 SDR family oxidoreductase -
DM40_RS12635 1975722..1976579 - 858 WP_040140234.1 IclR family transcriptional regulator Antitoxin
DM40_RS12640 1976576..1977472 - 897 WP_040140235.1 alpha/beta fold hydrolase Toxin
DM40_RS12645 1977491..1978018 - 528 WP_040140236.1 cupin domain-containing protein -
DM40_RS12650 1978053..1978823 - 771 WP_040140237.1 SDR family oxidoreductase -
DM40_RS12655 1978816..1979886 - 1071 WP_040140238.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
DM40_RS12660 1979947..1980258 - 312 WP_040140239.1 hypothetical protein -
DM40_RS12665 1980260..1980577 - 318 WP_011354710.1 non-heme iron oxygenase ferredoxin subunit -
DM40_RS12670 1981025..1982104 + 1080 WP_040140240.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30755.04 Da        Isoelectric Point: 8.0700

>T47002 WP_040140235.1 NZ_CP007780:c1977472-1976576 [Burkholderia cenocepacia]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGATGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGASTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIIAGGLARVMPARIAGLLLISPAGGYGSAPAETR
DTRRDARLAMLAELGPAGLAEQRSGNMLSGFAGEEARAWVRWNMARIVPAGYAQATHLLANADLASDLAGFRGRTAVAVG
AHDAITPPAACERIAAAAHVKLQVIPQAGHAGYVEAPAVYSSLIDAFCRQCDRQPGLE

Download         Length: 897 bp

>T47002 NZ_CP007780:c1977472-1976576 [Burkholderia cenocepacia]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAACAGCGTTG
CGCGGCCGGCGCGACGGGCACGATCGGCTATCGTGAGGCCGGCGCGCAGCACGCAGGCCGCGCGCTGCCCGTCGTGCTGC
TGCACGGGATCGGCTCGGGCGCCGCATCGTGGGTGCGCCAGCTCGACACGCTAGGTGCGTCGCGGCGCGTGCTCGCGTGG
GATGCGCCCGGCTACGGCGCGTCGACGCCCGTGCACGGCGCGTCGCCGGCGGCGGCCGATTACGCGGCGTCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGGCATTCGCTCGGCGCGATCATCGCGGGCGGGTTGGCAC
GCGTGATGCCTGCGCGGATCGCCGGCCTGCTGCTGATCTCGCCCGCGGGCGGCTACGGCAGCGCGCCCGCCGAAACGCGC
GACACGCGGCGCGATGCGCGTCTCGCGATGCTCGCGGAACTCGGCCCGGCCGGGCTCGCGGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGGGCGAGGAAGCACGTGCATGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTATGCGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGTCCGACCTCGCCGGTTTTCGCGGCCGCACGGCGGTCGCGGTCGGT
GCACACGACGCGATCACGCCGCCCGCTGCATGCGAGCGGATCGCCGCGGCCGCGCACGTGAAGCTGCAGGTGATTCCGCA
GGCCGGTCATGCGGGTTACGTCGAAGCGCCGGCCGTTTATTCATCGCTGATCGATGCGTTCTGCCGCCAATGCGATCGTC
AACCGGGGCTGGAATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31280.71 Da        Isoelectric Point: 6.3584

>AT47002 WP_040140234.1 NZ_CP007780:c1976579-1975722 [Burkholderia cenocepacia]
MSEPLERQDTENAKSEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLAELRALYPEGTLNQMTSATPATVDALYETIREDALRGYGVSNSSFERGISVVTAPVRNDTQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT47002 NZ_CP007780:c1976579-1975722 [Burkholderia cenocepacia]
ATGAGCGAACCGCTGGAACGCCAGGACACGGAAAACGCGAAGTCCGAAGCCAGCTACGTGGTGCCGGGCCTCGAACGCGG
TTTGCGGATCCTCGCCGAATTCTCGCCGCGCGAGCCGGTGCTGGGCGCGCCGGAACTGTCGAAGCGGCTCGGCATCCCCC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGCGCCGACAAGGATCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGTTTCGAATATCTGAGCTCGCTGGAGCTGACCGATCTCGGGCTGCCGGTGATCGA
GAGCCTGCGCGACGCGACCGGCTTCACGACGCACATCGTGATCCGCGACGGGCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGGCGCCGGTGTTCAGCTCGATTCGCGTGAACGTCGGCACGCGGCTGCCCGCGCACGCGACGACGCACGGCCAC
GTGCTGATGGGCGACCTGTCTCTCGCGGAGTTGCGCGCGTTGTATCCGGAAGGCACGCTGAACCAGATGACGAGCGCGAC
GCCGGCAACGGTCGACGCGCTTTATGAAACGATTCGCGAAGACGCGCTGCGCGGTTACGGCGTCAGCAATTCGTCGTTCG
AACGCGGGATCTCGGTGGTCACGGCGCCGGTGCGCAACGACACCCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGACCGGAGATCGACGCGGCGCTGATCGCCGACGGTCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCATACGTTTCTGAAGGCATTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References