Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 924469..925089 Replicon chromosome
Accession NZ_CP007780
Organism Burkholderia cenocepacia strain DWS 37E-2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag DM40_RS08145 Protein ID WP_144245394.1
Coordinates 924772..925089 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag DM40_RS08140 Protein ID WP_006756590.1
Coordinates 924469..924768 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM40_RS08115 919658..920929 + 1272 WP_040139278.1 Rieske 2Fe-2S domain-containing protein -
DM40_RS08120 920947..921432 + 486 WP_040139279.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
DM40_RS08125 921459..921785 + 327 WP_040139280.1 non-heme iron oxygenase ferredoxin subunit -
DM40_RS08130 921775..922995 + 1221 WP_040139281.1 FAD-dependent oxidoreductase -
DM40_RS08135 923148..924434 + 1287 WP_040139282.1 DUF445 domain-containing protein -
DM40_RS08140 924469..924768 - 300 WP_006756590.1 putative addiction module antidote protein Antitoxin
DM40_RS08145 924772..925089 - 318 WP_144245394.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DM40_RS08150 925482..927122 + 1641 WP_040139284.1 acetolactate synthase large subunit -
DM40_RS08155 927152..928585 + 1434 WP_040139285.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-101)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11960.59 Da        Isoelectric Point: 8.9048

>T47001 WP_144245394.1 NZ_CP007780:c925089-924772 [Burkholderia cenocepacia]
MPYSSPSYSIRTTDAFDAWFAALTDRVARRRIQARIDRLSMGNPGDWKSAGSPIVEMRIDHGPGYRVYYARRETIWVILL
CGGDKSTQQADIRAAHAMLERLDLE

Download         Length: 318 bp

>T47001 NZ_CP007780:c925089-924772 [Burkholderia cenocepacia]
ATGCCCTACAGTTCGCCTTCGTACAGTATCCGGACCACAGACGCCTTCGACGCGTGGTTTGCCGCCCTTACGGATCGCGT
CGCGCGGCGCCGCATCCAGGCGCGCATCGACCGTCTGTCGATGGGCAACCCGGGCGACTGGAAATCCGCCGGCTCACCGA
TCGTCGAAATGCGTATCGACCACGGCCCCGGCTATCGCGTCTACTACGCGAGGCGCGAAACGATATGGGTGATCCTGCTC
TGCGGCGGTGACAAGTCGACACAACAGGCGGACATCCGCGCCGCGCACGCGATGCTCGAACGGCTCGACCTGGAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10688.13 Da        Isoelectric Point: 6.6387

>AT47001 WP_006756590.1 NZ_CP007780:c924768-924469 [Burkholderia cenocepacia]
MDKIKTRPWDSAEHLKTDDDMAEYFEACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT47001 NZ_CP007780:c924768-924469 [Burkholderia cenocepacia]
ATGGACAAGATCAAGACCCGGCCGTGGGATTCGGCCGAACACCTGAAAACCGACGACGACATGGCCGAGTATTTCGAGGC
CTGTCTGCAGGAAGCCGGCGACGACCCGGCCTTCATCGCGCATGCGCTTGGCGTGATCGCGCGCGCGCGCGGGATGTCGC
AGGTCGCGCGCGACGCCGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTGAAAGTGATCAAGGCGCTCGGCCTGCAGCTGCACGGCGCGAAGGCGCACGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References