Detailed information of TA system TA046992

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 3387369..3388024
• Replicon: chromosome
• Accession: NZ_CP007748
• Organism: Burkholderia cepacia ATCC 25416

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: U2HGC0
• Locus tag: DM41_RS40230
• Protein ID: WP_021158162.1
• Coordinates: 3387369..3387788 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: U2HMP5
• Locus tag: DM41_RS40235
• Protein ID: WP_021158161.1
• Coordinates: 3387785..3388024 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DM41_RS40205	3382726..3383520	+	795	WP_027789489.1	AraC family transcriptional regulator	-
DM41_RS40210	3383780..3384733	+	954	WP_027789490.1	DMT family transporter	-
DM41_RS40215	3384918..3385466	+	549	WP_027789491.1	hypothetical protein	-
DM41_RS40220	3385570..3385704	-	135	WP_021158165.1	entericidin A/B family lipoprotein	-
DM41_RS40225	3385938..3387233	+	1296	WP_027789492.1	aspartate carbamoyltransferase	-
DM41_RS40230	3387369..3387788	-	420	WP_021158162.1	type II toxin-antitoxin system VapC family toxin	Toxin
DM41_RS40235	3387785..3388024	-	240	WP_021158161.1	antitoxin VapB	Antitoxin
DM41_RS40240	3388334..3390579	+	2246	Protein_3024	TonB-dependent siderophore receptor	-
DM41_RS40245	3390583..3391338	+	756	WP_027789495.1	sel1 repeat family protein	-
DM41_RS40250	3391335..3392018	+	684	WP_027789496.1	Fe2+-dependent dioxygenase	-
DM41_RS40255	3392107..3392346	+	240	WP_011659184.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
DM41_RS40260	3392343..3392738	+	396	WP_027789497.1	type II toxin-antitoxin system VapC family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15212.57 Da
• Isoelectric Point: 5.9052

>T46992 WP_021158162.1 NZ_CP007748:c3387788-3387369 [Burkholderia cepacia ATCC 25416]
MILVDTNVISEPLRREPNAAVIEWLDAQNVETLFLAAISLAEIRLGVAVLPEGRRREWLHQSIEQRVLPLFRGRILPFDD
AASKAYASLRARARAAGVAIAPSDGFIAGTAEANGLIVATRDVTPFEAMGIRVIDPWAR

Nucleotide

• Length: 420 bp

>T46992 NZ_CP007748:c3387788-3387369 [Burkholderia cepacia ATCC 25416]
ATGATCCTTGTTGATACGAATGTCATTTCCGAACCGCTACGACGCGAGCCGAACGCGGCCGTGATCGAGTGGCTCGATGC
CCAGAATGTCGAAACCTTGTTTCTGGCTGCGATCAGTCTCGCGGAAATACGATTGGGCGTGGCTGTATTGCCGGAAGGAC
GCCGGCGAGAGTGGCTGCATCAGAGCATCGAGCAGCGCGTGCTGCCATTGTTTCGCGGACGAATCCTGCCATTCGACGAT
GCTGCGAGCAAAGCGTATGCGAGCCTTCGCGCACGCGCTCGTGCCGCAGGTGTCGCAATTGCACCATCCGATGGTTTTAT
CGCCGGCACGGCCGAAGCGAACGGCCTGATCGTCGCCACGCGCGATGTCACGCCGTTCGAGGCAATGGGAATTCGCGTAA
TCGACCCGTGGGCGCGCTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8629.79 Da
• Isoelectric Point: 5.6643

>AT46992 WP_021158161.1 NZ_CP007748:c3388024-3387785 [Burkholderia cepacia ATCC 25416]
MPVITVRNLSDEVHRALRIRAAQHGRSTEAEVRDILEQAVLPGGRLKLGTMLAAIGQEAGGFDFDAQRDKTPADPMSFE

Nucleotide

• Length: 240 bp

>AT46992 NZ_CP007748:c3388024-3387785 [Burkholderia cepacia ATCC 25416]
ATGCCGGTGATCACCGTCCGAAATCTGTCCGATGAAGTGCATCGAGCACTTCGCATTCGCGCGGCCCAACATGGGCGCAG
CACCGAAGCCGAGGTGCGCGACATTCTCGAACAGGCCGTTCTTCCGGGCGGGCGGCTCAAGCTGGGAACGATGCTGGCGG
CAATCGGGCAGGAGGCCGGCGGATTCGATTTCGACGCCCAGCGCGACAAGACGCCTGCCGATCCGATGAGCTTCGAATGA

Structures

Toxin

• AlphaFold DB: U2HGC0

Antitoxin

• AlphaFold DB: U2HMP5