Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 1520011..1520648 Replicon chromosome
Accession NZ_CP007746
Organism Burkholderia cepacia ATCC 25416

Toxin (Protein)


Gene name vapC Uniprot ID A0A806UUZ0
Locus tag DM41_RS08365 Protein ID WP_027788677.1
Coordinates 1520247..1520648 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A1Z3YWA1
Locus tag DM41_RS08360 Protein ID WP_027788678.1
Coordinates 1520011..1520247 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM41_RS08340 1515989..1517131 - 1143 WP_049097352.1 ADP-heptose--LPS heptosyltransferase -
DM41_RS08345 1517128..1518831 - 1704 WP_027788681.1 thiamine pyrophosphate-binding protein -
DM41_RS08350 1519132..1519593 + 462 WP_027788680.1 hypothetical protein -
DM41_RS08355 1519590..1519874 + 285 WP_027788679.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
DM41_RS08360 1520011..1520247 + 237 WP_027788678.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DM41_RS08365 1520247..1520648 + 402 WP_027788677.1 type II toxin-antitoxin system VapC family toxin Toxin
DM41_RS08370 1520715..1522103 - 1389 WP_027788676.1 L-serine ammonia-lyase -
DM41_RS08375 1522134..1523270 - 1137 WP_027788675.1 alginate lyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

SpoVT-AbrB domain

(7-46)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14959.06 Da        Isoelectric Point: 5.1684

>T46982 WP_027788677.1 NZ_CP007746:1520247-1520648 [Burkholderia cepacia ATCC 25416]
MPRYMLDTNMCIYLMKNQPEQVAKQFAQCYTGDVVMSAITYAELEYGVAACANPARERRHLAALIDDIPVAPFDVAAAQA
YGPVRDATRERKRDHLDKLIAAHAVSLDVALVTNNERDFVSYPGLRLENWLND

Download         Length: 402 bp

>T46982 NZ_CP007746:1520247-1520648 [Burkholderia cepacia ATCC 25416]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTATCTGATGAAGAACCAGCCCGAGCAAGTCGCGAAACAATTTGC
GCAGTGCTACACGGGGGATGTGGTGATGTCGGCGATCACGTATGCCGAGCTCGAGTACGGCGTCGCCGCATGTGCGAATC
CTGCGCGGGAGCGTCGCCATCTCGCCGCGCTGATCGACGATATCCCCGTTGCTCCGTTCGACGTCGCGGCGGCGCAAGCG
TACGGTCCGGTCCGCGACGCAACCCGCGAGCGGAAGAGGGATCATCTCGACAAGCTGATCGCCGCGCACGCGGTGTCGCT
CGACGTTGCGCTCGTGACCAACAACGAGCGGGATTTCGTCAGCTATCCGGGATTGCGGCTGGAGAACTGGCTGAACGATT
GA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9144.34 Da        Isoelectric Point: 5.1974

>AT46982 WP_027788678.1 NZ_CP007746:1520011-1520247 [Burkholderia cepacia ATCC 25416]
MHTTKVFRNGNSQAVRIPADLAYERNDIELEIERIGDEIRIRPMRRPLTRVLEKFAKFGPDFMAEGRGDQEQADREEL

Download         Length: 237 bp

>AT46982 NZ_CP007746:1520011-1520247 [Burkholderia cepacia ATCC 25416]
ATGCACACGACGAAGGTATTTCGGAACGGCAACTCGCAGGCCGTGCGAATTCCTGCCGACCTCGCCTATGAGCGTAACGA
TATCGAACTGGAAATCGAGCGTATCGGTGACGAAATCCGTATTCGACCGATGCGGCGGCCGTTGACCCGCGTACTCGAGA
AGTTCGCGAAATTCGGGCCGGATTTCATGGCCGAAGGGCGCGGCGACCAGGAGCAGGCCGATCGCGAGGAGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806UUZ0

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3YWA1

References