46976

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1307380..1308005 Replicon chromosome
Accession NZ_CP007744
Organism Pectobacterium atrosepticum strain JG10-08

Toxin (Protein)


Gene name Hha Uniprot ID Q6D810
Locus tag EV46_RS05765 Protein ID WP_011092758.1
Coordinates 1307380..1307583 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q6D809
Locus tag EV46_RS05770 Protein ID WP_010282247.1
Coordinates 1307637..1308005 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EV46_RS05740 1302857..1303195 + 339 WP_002208627.1 P-II family nitrogen regulator -
EV46_RS05745 1303235..1304521 + 1287 WP_039290645.1 ammonium transporter AmtB -
EV46_RS05750 1304639..1305502 - 864 WP_011092755.1 acyl-CoA thioesterase II -
EV46_RS05755 1305715..1306296 + 582 WP_011092756.1 YbaY family lipoprotein -
EV46_RS05760 1306316..1306636 - 321 WP_011092757.1 MGMT family protein -
EV46_RS05765 1307380..1307583 - 204 WP_011092758.1 hemolysin expression modulator Hha Toxin
EV46_RS05770 1307637..1308005 - 369 WP_010282247.1 Hha toxicity modulator TomB Antitoxin
EV46_RS22340 1308604..1308747 - 144 WP_005976091.1 type B 50S ribosomal protein L36 -
EV46_RS05775 1308765..1309013 - 249 WP_011092759.1 type B 50S ribosomal protein L31 -
EV46_RS05780 1309219..1312347 - 3129 WP_011092760.1 multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8159.55 Da        Isoelectric Point: 8.9008

>T46976 WP_011092758.1 NZ_CP007744:c1307583-1307380 [Pectobacterium atrosepticum]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKIPTAVWRYVR

Download         Length: 204 bp

>T46976 NZ_CP007744:c1307583-1307380 [Pectobacterium atrosepticum]
ATGAAAAAAATCGACTATTTGATGCGTTTGCGTAAATGCACAACCATTGACACACTCGAACGTGTTATTGAAAAAAACAA
GTATGAGCTCTCCAATGATGAACTGGAGATGTTCTTTTCAGCAGCCGATCATCGCCTGGCTGAACTGACAATGAACAAAC
TCTACGACAAAATCCCTACCGCAGTATGGCGCTACGTACGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14046.80 Da        Isoelectric Point: 4.4787

>AT46976 WP_010282247.1 NZ_CP007744:c1308005-1307637 [Pectobacterium atrosepticum]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENICTPAKT

Download         Length: 369 bp

>AT46976 NZ_CP007744:c1308005-1307637 [Pectobacterium atrosepticum]
ATGGATGAGTACACACCGAAACATTATGATATTGCCCAACTCAGATTCTTATGTGAGAATCTGTGTGACGAAAGCATAGC
AACGTTAGGCGATAGCAGTCACGGCTGGGTCAATGATCCAACATCTGCGATCAATCTCCAATTAAATGAACTTATTGAGC
ATATCGCTACGTTTATTCTCACATTTAAAATAAAATACCCTAACGAAAGTGAGCTTTCAGAGCAGGTTGAAAAGTATTTG
GATGATACTTACGTCTTGTTTAGCAACTATGGCATTAATGATGCTGAACTACGACGCTGGCAGAAATCCAAAGCAAAATT
ATTCGGAATGTTCTCAGGGGAGAACATCTGTACGCCTGCTAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J5XPH8

Antitoxin

Source ID Structure
AlphaFold DB A0A086EI31

References