Detailed information of TA system TA046975

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 812278..812803
• Replicon: chromosome
• Accession: NZ_CP007744
• Organism: Pectobacterium atrosepticum strain JG10-08

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EV46_RS03610
• Protein ID: WP_039290137.1
• Coordinates: 812278..812562 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C6D956
• Locus tag: EV46_RS03615
• Protein ID: WP_005973616.1
• Coordinates: 812552..812803 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EV46_RS03585	807610..808071	-	462	Protein_693	hypothetical protein	-
EV46_RS22060	808926..809558	-	633	WP_158296417.1	transglycosylase domain-containing protein	-
EV46_RS23225	809495..810115	-	621	WP_158296418.1	hypothetical protein	-
EV46_RS22865	810418..810797	-	380	Protein_696	winged helix-turn-helix domain-containing protein	-
EV46_RS03600	811221..811766	+	546	WP_039282029.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-
EV46_RS03605	811750..811950	+	201	Protein_698	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
EV46_RS03610	812278..812562	-	285	WP_039290137.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EV46_RS03615	812552..812803	-	252	WP_005973616.1	prevent-host-death protein	Antitoxin
EV46_RS03620	813063..815390	-	2328	WP_039290139.1	toprim domain-containing protein	-
EV46_RS03625	815401..815742	-	342	WP_039290142.1	DUF5375 family protein	-
EV46_RS03630	815739..816005	-	267	WP_039290145.1	hypothetical protein	-
EV46_RS03635	816002..816196	-	195	WP_039294697.1	hypothetical protein	-
EV46_RS23005	816189..816386	-	198	WP_039294701.1	host cell division inhibitor Icd-like protein	-
EV46_RS22260	816365..816733	-	369	Protein_706	ash family protein	-
EV46_RS03650	816742..816966	-	225	WP_039281995.1	hypothetical protein	-
EV46_RS03655	816963..817223	-	261	WP_039290147.1	AlpA family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	799166..876010	76844

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10907.88 Da
• Isoelectric Point: 10.1988

>T46975 WP_039290137.1 NZ_CP007744:c812562-812278 [Pectobacterium atrosepticum]
MSYKLEFEEHALKEFKKLGAPVRELFTKKLKAVLQNPHVPANRLHGMADCYKIKLRSAGYRLVYQVLEHEIVVLVLAVGK
RERSEVYQAAKDRL

Nucleotide

• Length: 285 bp

>T46975 NZ_CP007744:c812562-812278 [Pectobacterium atrosepticum]
ATGAGTTATAAGCTGGAGTTTGAAGAGCACGCGCTGAAAGAATTTAAGAAGCTGGGTGCACCCGTGCGGGAGCTGTTCAC
CAAAAAGCTGAAAGCGGTTTTACAAAATCCCCACGTTCCCGCCAACCGACTTCATGGAATGGCTGACTGCTACAAAATCA
AACTTCGTTCCGCTGGCTATCGGCTAGTGTATCAAGTGCTTGAGCATGAGATCGTAGTACTGGTTTTAGCTGTGGGCAAG
CGTGAACGCTCAGAGGTTTATCAAGCAGCCAAAGACCGACTATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9079.35 Da
• Isoelectric Point: 5.0807

>AT46975 WP_005973616.1 NZ_CP007744:c812803-812552 [Pectobacterium atrosepticum]
MSVQPILANAAVSISDFKKSPNAALKEANGEPVAVLTNGRISGYYVSPETWEALADYQEDIELAKIARSRMKGKRVKVDL
DEL

Nucleotide

• Length: 252 bp

>AT46975 NZ_CP007744:c812803-812552 [Pectobacterium atrosepticum]
ATGTCCGTGCAACCTATTCTTGCCAATGCTGCCGTGAGTATTAGCGACTTTAAAAAATCGCCCAATGCAGCGTTGAAAGA
AGCTAACGGCGAGCCTGTAGCCGTGTTAACCAATGGCCGTATCTCTGGCTATTATGTTTCCCCGGAAACATGGGAAGCGC
TGGCCGACTATCAGGAAGATATCGAACTTGCCAAAATTGCCCGCTCCCGGATGAAGGGGAAACGTGTGAAGGTCGATCTG
GATGAGTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A0G4JQP6