Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1140744..1141273 Replicon chromosome
Accession NZ_CP007724
Organism Corynebacterium glutamicum strain AR1

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag CGLAR1_RS15035 Protein ID WP_080724094.1
Coordinates 1140974..1141273 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag CGLAR1_RS05415 Protein ID WP_038583360.1
Coordinates 1140744..1140977 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CGLAR1_RS05395 1136801..1138012 - 1212 WP_038583347.1 esterase family protein -
CGLAR1_RS05400 1138208..1139293 + 1086 WP_038583350.1 redox-regulated ATPase YchF -
CGLAR1_RS05405 1139458..1139847 + 390 WP_038583354.1 hypothetical protein -
CGLAR1_RS05410 1140036..1140476 + 441 WP_038583357.1 YtoQ family protein -
CGLAR1_RS05415 1140744..1140977 + 234 WP_038583360.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
CGLAR1_RS15035 1140974..1141273 + 300 WP_080724094.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CGLAR1_RS05420 1141312..1141578 + 267 WP_143855333.1 helix-turn-helix transcriptional regulator -
CGLAR1_RS05425 1141796..1142152 - 357 WP_051904590.1 hypothetical protein -
CGLAR1_RS14810 1142211..1142723 - 513 WP_145973356.1 hypothetical protein -
CGLAR1_RS05435 1142943..1143401 + 459 WP_038583364.1 NUDIX domain-containing protein -
CGLAR1_RS15040 1143576..1143671 + 96 Protein_1061 CGNR zinc finger domain-containing protein -
CGLAR1_RS05440 1143787..1144323 - 537 WP_051907073.1 hypothetical protein -
CGLAR1_RS05445 1144346..1144714 - 369 WP_038583367.1 SMI1/KNR4 family protein -
CGLAR1_RS05450 1144832..1145326 + 495 WP_038583369.1 2'-5' RNA ligase -
CGLAR1_RS05455 1145423..1145929 + 507 WP_038586898.1 hemerythrin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-74)

Antitoxin

Antitoxin ParD

(1-76)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11462.00 Da        Isoelectric Point: 10.2383

>T46921 WP_080724094.1 NZ_CP007724:1140974-1141273 [Corynebacterium glutamicum]
VSRYLLTPAAQHDLSLIWDFTESRWGISQAKKYIREIQSAVEYVAQDANRGCSREEIRVGYKSTAVGSHVIFYVQRTSHW
KAMKQPVWRPTSARQFVTS

Download         Length: 300 bp

>T46921 NZ_CP007724:1140974-1141273 [Corynebacterium glutamicum]
GTGAGCAGGTACCTTCTTACACCGGCTGCACAGCATGATCTCTCCTTGATTTGGGATTTCACCGAGAGTCGTTGGGGTAT
AAGCCAAGCAAAGAAGTATATCCGTGAGATTCAATCAGCAGTGGAATATGTGGCACAAGATGCGAACCGTGGCTGTAGTC
GTGAGGAAATTCGCGTAGGTTATAAAAGCACTGCGGTAGGCAGCCATGTCATATTTTATGTCCAGCGCACGAGCCATTGG
AAGGCAATGAAACAGCCTGTCTGGAGACCGACATCGGCCAGGCAGTTCGTGACCTCATAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8474.45 Da        Isoelectric Point: 4.4143

>AT46921 WP_038583360.1 NZ_CP007724:1140744-1140977 [Corynebacterium glutamicum]
MAMNTSISLDDHFASFLSEQVESGRYQTASEVIRAGLRLLEEREARLTALRAALVNGKMSGEAEEFDFDAFIASKSS

Download         Length: 234 bp

>AT46921 NZ_CP007724:1140744-1140977 [Corynebacterium glutamicum]
ATGGCCATGAATACTTCCATCAGTCTTGATGATCATTTCGCTTCGTTCCTCAGTGAGCAGGTTGAATCCGGTCGGTACCA
GACAGCGAGTGAGGTCATCCGTGCAGGTCTGCGCTTGTTGGAGGAGCGGGAAGCTCGTCTAACTGCTTTACGTGCGGCGC
TTGTAAATGGAAAGATGAGTGGTGAGGCAGAAGAATTTGATTTTGATGCCTTTATCGCATCGAAAAGCTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References