Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1171561..1172090 Replicon chromosome
Accession NZ_CP007722
Organism Corynebacterium glutamicum strain ATCC 21831

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag AR0_RS15185 Protein ID WP_080724094.1
Coordinates 1171791..1172090 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag AR0_RS05530 Protein ID WP_038583360.1
Coordinates 1171561..1171794 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AR0_RS05510 1167618..1168829 - 1212 WP_038583347.1 esterase family protein -
AR0_RS05515 1169025..1170110 + 1086 WP_038583350.1 redox-regulated ATPase YchF -
AR0_RS05520 1170275..1170664 + 390 WP_038583354.1 hypothetical protein -
AR0_RS05525 1170853..1171293 + 441 WP_038583357.1 YtoQ family protein -
AR0_RS05530 1171561..1171794 + 234 WP_038583360.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
AR0_RS15185 1171791..1172090 + 300 WP_080724094.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AR0_RS05535 1172129..1172395 + 267 WP_143855333.1 helix-turn-helix transcriptional regulator -
AR0_RS05540 1172613..1172969 - 357 WP_051904590.1 hypothetical protein -
AR0_RS14940 1173028..1173540 - 513 WP_145973356.1 hypothetical protein -
AR0_RS05550 1173760..1174218 + 459 WP_038583364.1 NUDIX domain-containing protein -
AR0_RS15190 1174393..1174488 + 96 Protein_1087 CGNR zinc finger domain-containing protein -
AR0_RS05555 1174604..1175140 - 537 WP_051907073.1 hypothetical protein -
AR0_RS05560 1175163..1175531 - 369 WP_038583367.1 SMI1/KNR4 family protein -
AR0_RS05565 1175649..1176143 + 495 WP_038583369.1 2'-5' RNA ligase -
AR0_RS05570 1176240..1176746 + 507 WP_038586898.1 hemerythrin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-74)

Antitoxin

Antitoxin ParD

(1-76)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11462.00 Da        Isoelectric Point: 10.2383

>T46920 WP_080724094.1 NZ_CP007722:1171791-1172090 [Corynebacterium glutamicum]
VSRYLLTPAAQHDLSLIWDFTESRWGISQAKKYIREIQSAVEYVAQDANRGCSREEIRVGYKSTAVGSHVIFYVQRTSHW
KAMKQPVWRPTSARQFVTS

Download         Length: 300 bp

>T46920 NZ_CP007722:1171791-1172090 [Corynebacterium glutamicum]
GTGAGCAGGTACCTTCTTACACCGGCTGCACAGCATGATCTCTCCTTGATTTGGGATTTCACCGAGAGTCGTTGGGGTAT
AAGCCAAGCAAAGAAGTATATCCGTGAGATTCAATCAGCAGTGGAATATGTGGCACAAGATGCGAACCGTGGCTGTAGTC
GTGAGGAAATTCGCGTAGGTTATAAAAGCACTGCGGTAGGCAGCCATGTCATATTTTATGTCCAGCGCACGAGCCATTGG
AAGGCAATGAAACAGCCTGTCTGGAGACCGACATCGGCCAGGCAGTTCGTGACCTCATAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8474.45 Da        Isoelectric Point: 4.4143

>AT46920 WP_038583360.1 NZ_CP007722:1171561-1171794 [Corynebacterium glutamicum]
MAMNTSISLDDHFASFLSEQVESGRYQTASEVIRAGLRLLEEREARLTALRAALVNGKMSGEAEEFDFDAFIASKSS

Download         Length: 234 bp

>AT46920 NZ_CP007722:1171561-1171794 [Corynebacterium glutamicum]
ATGGCCATGAATACTTCCATCAGTCTTGATGATCATTTCGCTTCGTTCCTCAGTGAGCAGGTTGAATCCGGTCGGTACCA
GACAGCGAGTGAGGTCATCCGTGCAGGTCTGCGCTTGTTGGAGGAGCGGGAAGCTCGTCTAACTGCTTTACGTGCGGCGC
TTGTAAATGGAAAGATGAGTGGTGAGGCAGAAGAATTTGATTTTGATGCCTTTATCGCATCGAAAAGCTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References