Detailed information of TA system TA046913

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 1946739..1947249
• Replicon: chromosome
• Accession: NZ_CP007712
• Organism: Acinetobacter baumannii LAC-4

Toxin (Protein)

• Gene name: relB
• Uniprot ID: A0A4Q4HKU6
• Locus tag: RR41_RS09405
• Protein ID: WP_000824257.1
• Coordinates: 1946739..1947002 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7S8XU62
• Locus tag: RR41_RS09410
• Protein ID: WP_001165438.1
• Coordinates: 1946986..1947249 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RR41_RS09385	1942849..1944036	+	1188	WP_002036368.1	DUF4268 domain-containing protein	-
RR41_RS09390	1944109..1945692	-	1584	WP_005080579.1	IS66-like element ISAba25 family transposase	-
RR41_RS09395	1945767..1946102	-	336	WP_000618091.1	IS66 family insertion sequence element accessory protein TnpB	-
RR41_RS09400	1946099..1946482	-	384	WP_001055585.1	IS66 family insertion sequence hypothetical protein	-
RR41_RS09405	1946739..1947002	-	264	WP_000824257.1	Txe/YoeB family addiction module toxin	Toxin
RR41_RS09410	1946986..1947249	-	264	WP_001165438.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
RR41_RS09415	1947603..1947869	-	267	WP_000570798.1	AlpA family phage regulatory protein	-
RR41_RS09420	1947866..1948894	-	1029	WP_001101792.1	hypothetical protein	-
RR41_RS09425	1948891..1950114	-	1224	WP_000261481.1	inovirus-type Gp2 protein	-
RR41_RS09430	1950425..1951357	-	933	WP_001043692.1	IS5-like element ISAba13 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	1944109..1951357	7248

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10337.91 Da
• Isoelectric Point: 9.0098

>T46913 WP_000824257.1 NZ_CP007712:c1947002-1946739 [Acinetobacter baumannii LAC-4]
MKRKTSFTPTAWEDYVYWQNQDKKTLKRINTLIKECLRTPFDGIGKPEPLLGDLAGLWSRRIDEKNRLVYEVTDVAITII
SCRYHYE

Nucleotide

• Length: 264 bp

>T46913 NZ_CP007712:c1947002-1946739 [Acinetobacter baumannii LAC-4]
ATGAAACGGAAGACTAGTTTTACTCCAACAGCTTGGGAGGATTATGTATATTGGCAAAACCAAGACAAAAAGACTCTTAA
GCGCATCAATACATTAATCAAAGAGTGTCTTCGTACCCCCTTTGATGGTATTGGCAAGCCTGAACCATTACTCGGTGATT
TAGCAGGTTTGTGGAGCAGACGAATAGATGAAAAAAATAGATTAGTCTATGAAGTAACTGATGTAGCGATAACTATCATT
TCTTGTCGTTATCACTACGAATAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9796.01 Da
• Isoelectric Point: 4.6112

>AT46913 WP_001165438.1 NZ_CP007712:c1947249-1946986 [Acinetobacter baumannii LAC-4]
MQIFTYTDARNNLKTVLDRVIDDSDVAVITRKEGQHAVVMGQDYYNSIMETLHLMSSPSNAAHLAKSIAELRASKAIERE
LLDETED

Nucleotide

• Length: 264 bp

>AT46913 NZ_CP007712:c1947249-1946986 [Acinetobacter baumannii LAC-4]
ATGCAAATTTTCACTTATACCGATGCTCGCAATAATCTGAAAACGGTTTTAGACCGTGTCATTGATGATTCAGATGTTGC
AGTAATTACGAGAAAAGAAGGTCAACATGCAGTTGTAATGGGACAAGACTATTACAATAGTATAATGGAGACATTGCACC
TCATGTCTTCTCCAAGTAATGCAGCACACCTAGCGAAATCAATTGCAGAATTACGGGCATCTAAAGCAATCGAAAGAGAA
CTTTTAGATGAAACGGAAGACTAG

Structures

Toxin

• AlphaFold DB: A0A4Q4HKU6