Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 471626..472279 Replicon chromosome
Accession NZ_CP007712
Organism Acinetobacter baumannii LAC-4

Toxin (Protein)


Gene name cptA Uniprot ID A0A5N0FZY3
Locus tag RR41_RS02310 Protein ID WP_000607074.1
Coordinates 471890..472279 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag RR41_RS02305 Protein ID WP_001288210.1
Coordinates 471626..471883 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RR41_RS02285 467142..468149 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
RR41_RS02290 468168..468545 + 378 WP_001216380.1 50S ribosomal protein L17 -
RR41_RS02295 468726..470216 + 1491 WP_000415136.1 NAD(P)/FAD-dependent oxidoreductase -
RR41_RS02300 470266..471438 - 1173 WP_001190545.1 acyl-CoA dehydrogenase family protein -
RR41_RS02305 471626..471883 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
RR41_RS02310 471890..472279 + 390 WP_000607074.1 membrane protein Toxin
RR41_RS02315 473049..474134 + 1086 WP_000049106.1 hypothetical protein -
RR41_RS02320 474212..474778 + 567 WP_000651536.1 rhombosortase -
RR41_RS02325 474966..477161 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15621.89 Da        Isoelectric Point: 10.3890

>T46912 WP_000607074.1 NZ_CP007712:471890-472279 [Acinetobacter baumannii LAC-4]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T46912 NZ_CP007712:471890-472279 [Acinetobacter baumannii LAC-4]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAGTAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT46912 WP_001288210.1 NZ_CP007712:471626-471883 [Acinetobacter baumannii LAC-4]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT46912 NZ_CP007712:471626-471883 [Acinetobacter baumannii LAC-4]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5N0FZY3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References