Detailed information of TA system TA046908

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 3231340..3231892
• Replicon: chromosome
• Accession: NZ_CP007699
• Organism: Streptomyces lydicus strain A02

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: T261_RS14585
• Protein ID: WP_046926201.1
• Coordinates: 3231614..3231892 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0D4DM31
• Locus tag: T261_RS14580
• Protein ID: WP_046926200.1
• Coordinates: 3231340..3231606 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
T261_RS14560	3226573..3227325	-	753	WP_046926196.1	GntR family transcriptional regulator	-
T261_RS14565	3227685..3228449	+	765	WP_046926197.1	PIG-L family deacetylase	-
T261_RS14570	3228446..3229414	-	969	WP_046926198.1	alpha/beta hydrolase	-
T261_RS14575	3229641..3231014	-	1374	WP_159031547.1	hypothetical protein	-
T261_RS14580	3231340..3231606	+	267	WP_046926200.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
T261_RS14585	3231614..3231892	+	279	WP_046926201.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
T261_RS14590	3231993..3233081	-	1089	WP_046926202.1	redox-regulated ATPase YchF	-
T261_RS14595	3233929..3234774	-	846	WP_046926203.1	ROK family protein	-
T261_RS14600	3234828..3235820	-	993	WP_046930819.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (13-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (6-59)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10471.97 Da
• Isoelectric Point: 10.2781

>T46908 WP_046926201.1 NZ_CP007699:3231614-3231892 [Streptomyces lydicus]
VSDNGATAYRTVFRPEARAELRKIPRDAALRILAKLTELEKDPYGFKTTALVSQPERRRLRVGDYRVVYTVDNGELVVWV
VHIGHRSTVYGS

Nucleotide

• Length: 279 bp

>T46908 NZ_CP007699:3231614-3231892 [Streptomyces lydicus]
GTGAGTGACAACGGCGCGACTGCCTACCGCACCGTCTTCCGTCCCGAGGCCCGGGCCGAACTCCGCAAGATCCCCCGGGA
CGCCGCGCTGCGCATCCTGGCCAAGCTGACCGAGCTGGAAAAGGACCCCTACGGCTTCAAGACCACCGCGCTCGTCTCCC
AGCCGGAGCGCCGCCGCCTCAGGGTCGGCGACTACCGCGTCGTCTACACCGTCGACAACGGCGAACTGGTCGTCTGGGTG
GTGCACATCGGACACCGGTCCACGGTCTACGGCAGCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10204.61 Da
• Isoelectric Point: 4.9473

>AT46908 WP_046926200.1 NZ_CP007699:3231340-3231606 [Streptomyces lydicus]
MTQMPIESIRDVRAHLAEVVERADRDDVPTVITRRGKEVAAVVSIEVLRKYQQWEEREINRIIDERMANRSAGTPIEDVM
KETLARSE

Nucleotide

• Length: 267 bp

>AT46908 NZ_CP007699:3231340-3231606 [Streptomyces lydicus]
ATGACGCAGATGCCCATAGAGTCCATCCGTGACGTCCGCGCGCACCTGGCCGAGGTCGTCGAGCGGGCCGACCGCGACGA
TGTCCCCACCGTCATCACCCGCCGCGGCAAGGAAGTCGCCGCCGTGGTGTCGATAGAGGTGCTGCGCAAGTACCAGCAGT
GGGAAGAGCGCGAGATCAACCGCATCATTGACGAGCGCATGGCGAACCGCTCCGCCGGCACCCCGATCGAGGACGTCATG
AAGGAGACGCTGGCGCGCAGTGAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0D4DM31