Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3231340..3231892 Replicon chromosome
Accession NZ_CP007699
Organism Streptomyces lydicus strain A02

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag T261_RS14585 Protein ID WP_046926201.1
Coordinates 3231614..3231892 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D4DM31
Locus tag T261_RS14580 Protein ID WP_046926200.1
Coordinates 3231340..3231606 (+) Length 89 a.a.

Genomic Context

T261_RS14565T261_RS14580T261_RS14585T261_RS14560T261_RS14570T261_RS14575T261_RS14590T261_RS14595T261_RS14600
Location: 3227685..3228449 (765 bp)
Type: Others
Protein ID: WP_046926197.1
Location: 3231340..3231606 (267 bp)
Type: Antitoxin
Protein ID: WP_046926200.1
Location: 3231614..3231892 (279 bp)
Type: Toxin
Protein ID: WP_046926201.1
Location: 3226573..3227325 (753 bp)
Type: Others
Protein ID: WP_046926196.1
Location: 3228446..3229414 (969 bp)
Type: Others
Protein ID: WP_046926198.1
Location: 3229641..3231014 (1374 bp)
Type: Others
Protein ID: WP_159031547.1
Location: 3231993..3233081 (1089 bp)
Type: Others
Protein ID: WP_046926202.1
Location: 3233929..3234774 (846 bp)
Type: Others
Protein ID: WP_046926203.1
Location: 3234828..3235820 (993 bp)
Type: Others
Protein ID: WP_046930819.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
T261_RS145603226573..3227325-753WP_046926196.1GntR family transcriptional regulator-
T261_RS145653227685..3228449+765WP_046926197.1PIG-L family deacetylase-
T261_RS145703228446..3229414-969WP_046926198.1alpha/beta hydrolase-
T261_RS145753229641..3231014-1374WP_159031547.1hypothetical protein-
T261_RS145803231340..3231606+267WP_046926200.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
T261_RS145853231614..3231892+279WP_046926201.1type II toxin-antitoxin system RelE/ParE family toxinToxin
T261_RS145903231993..3233081-1089WP_046926202.1redox-regulated ATPase YchF-
T261_RS145953233929..3234774-846WP_046926203.1ROK family protein-
T261_RS146003234828..3235820-993WP_046930819.14-hydroxy-3-methylbut-2-enyl diphosphate reductase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(13-90)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(6-59)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10471.97 Da        Isoelectric Point: 10.2781

>T46908 WP_046926201.1 NZ_CP007699:3231614-3231892 [Streptomyces lydicus]
VSDNGATAYRTVFRPEARAELRKIPRDAALRILAKLTELEKDPYGFKTTALVSQPERRRLRVGDYRVVYTVDNGELVVWV
VHIGHRSTVYGS

Download         Length: 279 bp

>T46908 NZ_CP007699:3231614-3231892 [Streptomyces lydicus]
GTGAGTGACAACGGCGCGACTGCCTACCGCACCGTCTTCCGTCCCGAGGCCCGGGCCGAACTCCGCAAGATCCCCCGGGA
CGCCGCGCTGCGCATCCTGGCCAAGCTGACCGAGCTGGAAAAGGACCCCTACGGCTTCAAGACCACCGCGCTCGTCTCCC
AGCCGGAGCGCCGCCGCCTCAGGGTCGGCGACTACCGCGTCGTCTACACCGTCGACAACGGCGAACTGGTCGTCTGGGTG
GTGCACATCGGACACCGGTCCACGGTCTACGGCAGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10204.61 Da        Isoelectric Point: 4.9473

>AT46908 WP_046926200.1 NZ_CP007699:3231340-3231606 [Streptomyces lydicus]
MTQMPIESIRDVRAHLAEVVERADRDDVPTVITRRGKEVAAVVSIEVLRKYQQWEEREINRIIDERMANRSAGTPIEDVM
KETLARSE

Download         Length: 267 bp

>AT46908 NZ_CP007699:3231340-3231606 [Streptomyces lydicus]
ATGACGCAGATGCCCATAGAGTCCATCCGTGACGTCCGCGCGCACCTGGCCGAGGTCGTCGAGCGGGCCGACCGCGACGA
TGTCCCCACCGTCATCACCCGCCGCGGCAAGGAAGTCGCCGCCGTGGTGTCGATAGAGGTGCTGCGCAAGTACCAGCAGT
GGGAAGAGCGCGAGATCAACCGCATCATTGACGAGCGCATGGCGAACCGCTCCGCCGGCACCCCGATCGAGGACGTCATG
AAGGAGACGCTGGCGCGCAGTGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0D4DM31

References