46888

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 883310..883787 Replicon chromosome
Accession NZ_CP007690
Organism Staphylococcus aureus strain UA-S391_USA300 isolate abscess/wound isolate

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag EX97_RS04315 Protein ID WP_000052078.1
Coordinates 883310..883498 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag EX97_RS04320 Protein ID WP_001059690.1
Coordinates 883527..883787 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EX97_RS04285 879351..879821 + 471 WP_000824472.1 hypothetical protein -
EX97_RS04290 880162..880848 + 687 WP_001548082.1 thermonuclease family protein -
EX97_RS04295 881205..881405 + 201 WP_001059082.1 cold-shock protein -
EX97_RS04300 881901..882119 - 219 WP_000005886.1 hypothetical protein -
EX97_RS04305 882181..882465 - 285 WP_001004395.1 hypothetical protein -
EX97_RS04310 882553..883122 - 570 WP_001106654.1 hypothetical protein -
EX97_RS04315 883310..883498 - 189 WP_000052078.1 hypothetical protein Toxin
EX97_RS04320 883527..883787 - 261 WP_001059690.1 hypothetical protein Antitoxin
EX97_RS04325 884128..884331 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
EX97_RS04330 884328..884564 - 237 WP_000368687.1 hypothetical protein -
EX97_RS04335 884789..885370 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
EX97_RS04340 885443..886060 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
EX97_RS04345 886215..886709 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
EX97_RS04350 887108..887530 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
EX97_RS04355 887678..888394 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T46888 WP_000052078.1 NZ_CP007690:c883498-883310 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T46888 NZ_CP007690:c883498-883310 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT46888 WP_001059690.1 NZ_CP007690:c883787-883527 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT46888 NZ_CP007690:c883787-883527 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References