Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2177557..2178071 Replicon chromosome
Accession NZ_CP007676
Organism Staphylococcus aureus strain HUV05

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag ER12_RS11080 Protein ID WP_000581792.1
Coordinates 2177557..2177766 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag ER12_RS11085 Protein ID WP_000138932.1
Coordinates 2177778..2178071 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ER12_RS11060 2173065..2174423 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
ER12_RS11065 2174438..2175508 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
ER12_RS11070 2175826..2177028 + 1203 WP_001109939.1 rod shape-determining protein RodA -
ER12_RS11075 2177292..2177429 - 138 WP_000828354.1 hypothetical protein -
ER12_RS11080 2177557..2177766 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
ER12_RS11085 2177778..2178071 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
ER12_RS11090 2178237..2179721 + 1485 WP_000571549.1 cardiolipin synthase -
ER12_RS11095 2179749..2180396 + 648 WP_001187629.1 HD domain-containing protein -
ER12_RS11110 2181209..2182081 - 873 WP_000725802.1 membrane protein insertase YidC -
ER12_RS11115 2182167..2182808 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T46879 WP_000581792.1 NZ_CP007676:c2177766-2177557 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T46879 NZ_CP007676:c2177766-2177557 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT46879 WP_000138932.1 NZ_CP007676:c2178071-2177778 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT46879 NZ_CP007676:c2178071-2177778 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References