Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 853649..854126 Replicon chromosome
Accession NZ_CP007676
Organism Staphylococcus aureus strain HUV05

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag ER12_RS04155 Protein ID WP_000052078.1
Coordinates 853649..853837 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag ER12_RS04160 Protein ID WP_001059690.1
Coordinates 853866..854126 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ER12_RS04125 849690..850160 + 471 WP_000824472.1 hypothetical protein -
ER12_RS04130 850501..851187 + 687 WP_001548082.1 thermonuclease family protein -
ER12_RS04135 851544..851744 + 201 WP_001059082.1 cold-shock protein -
ER12_RS04140 852240..852458 - 219 WP_000005886.1 hypothetical protein -
ER12_RS04145 852520..852804 - 285 WP_001004395.1 hypothetical protein -
ER12_RS04150 852892..853461 - 570 WP_001106654.1 hypothetical protein -
ER12_RS04155 853649..853837 - 189 WP_000052078.1 hypothetical protein Toxin
ER12_RS04160 853866..854126 - 261 WP_001059690.1 hypothetical protein Antitoxin
ER12_RS04165 854467..854670 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
ER12_RS04170 854667..854903 - 237 WP_000368687.1 hypothetical protein -
ER12_RS04175 855128..855709 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
ER12_RS04180 855782..856399 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
ER12_RS04185 856554..857048 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
ER12_RS04190 857447..857869 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
ER12_RS04195 858017..858733 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-113)

Antitoxin

Helix-turn-helix domain, group 17

(81-126)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T46870 WP_000052078.1 NZ_CP007676:c853837-853649 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T46870 NZ_CP007676:c853837-853649 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT46870 WP_001059690.1 NZ_CP007676:c854126-853866 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT46870 NZ_CP007676:c854126-853866 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References