Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 848666..849143 Replicon chromosome
Accession NZ_CP007674
Organism Staphylococcus aureus strain CA15

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag EQ90_RS04125 Protein ID WP_000052078.1
Coordinates 848666..848854 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag EQ90_RS04130 Protein ID WP_001059690.1
Coordinates 848883..849143 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQ90_RS04095 844707..845177 + 471 WP_000824472.1 hypothetical protein -
EQ90_RS04100 845518..846204 + 687 WP_001548082.1 thermonuclease family protein -
EQ90_RS04105 846561..846761 + 201 WP_001059082.1 cold-shock protein -
EQ90_RS04110 847257..847475 - 219 WP_000005886.1 hypothetical protein -
EQ90_RS04115 847537..847821 - 285 WP_001004395.1 hypothetical protein -
EQ90_RS04120 847909..848478 - 570 WP_001106654.1 hypothetical protein -
EQ90_RS04125 848666..848854 - 189 WP_000052078.1 hypothetical protein Toxin
EQ90_RS04130 848883..849143 - 261 WP_001059690.1 hypothetical protein Antitoxin
EQ90_RS04135 849484..849687 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
EQ90_RS04140 849684..849920 - 237 WP_000368687.1 hypothetical protein -
EQ90_RS04145 850146..850727 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
EQ90_RS04150 850800..851417 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
EQ90_RS04155 851572..852066 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
EQ90_RS04160 852465..852887 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
EQ90_RS04165 853035..853751 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp / selk / selq 830815..874433 43618


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-134)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T46854 WP_000052078.1 NZ_CP007674:c848854-848666 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T46854 NZ_CP007674:c848854-848666 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT46854 WP_001059690.1 NZ_CP007674:c849143-848883 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT46854 NZ_CP007674:c849143-848883 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References