Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 865069..865546 Replicon chromosome
Accession NZ_CP007672
Organism Staphylococcus aureus strain CA12

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag EQ80_RS04225 Protein ID WP_000052078.1
Coordinates 865069..865257 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag EQ80_RS04230 Protein ID WP_001059690.1
Coordinates 865286..865546 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EQ80_RS04195 861110..861580 + 471 WP_000824472.1 hypothetical protein -
EQ80_RS04200 861921..862607 + 687 WP_001548082.1 thermonuclease family protein -
EQ80_RS04205 862964..863164 + 201 WP_001059082.1 cold-shock protein -
EQ80_RS04210 863660..863878 - 219 WP_000005886.1 hypothetical protein -
EQ80_RS04215 863940..864224 - 285 WP_001004395.1 hypothetical protein -
EQ80_RS04220 864312..864881 - 570 WP_001106654.1 hypothetical protein -
EQ80_RS04225 865069..865257 - 189 WP_000052078.1 hypothetical protein Toxin
EQ80_RS04230 865286..865546 - 261 WP_001059690.1 hypothetical protein Antitoxin
EQ80_RS04235 865887..866090 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
EQ80_RS04240 866087..866323 - 237 WP_000368687.1 hypothetical protein -
EQ80_RS04245 866548..867129 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
EQ80_RS04250 867202..867819 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
EQ80_RS04255 867974..868468 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
EQ80_RS04260 868867..869289 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
EQ80_RS04265 869437..870153 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-69)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T46838 WP_000052078.1 NZ_CP007672:c865257-865069 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T46838 NZ_CP007672:c865257-865069 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT46838 WP_001059690.1 NZ_CP007672:c865546-865286 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT46838 NZ_CP007672:c865546-865286 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References