Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_19(antitoxin) |
| Location | 2041915..2042703 | Replicon | chromosome |
| Accession | NZ_CP007670 | ||
| Organism | Staphylococcus aureus strain M121 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A2C9TYR5 |
| Locus tag | EP54_RS10425 | Protein ID | WP_001573840.1 |
| Coordinates | 2042242..2042703 (+) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0E7YIA0 |
| Locus tag | EP54_RS10420 | Protein ID | WP_000333630.1 |
| Coordinates | 2041915..2042229 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EP54_RS10365 | 2037137..2037673 | - | 537 | WP_047335185.1 | host-nuclease inhibitor Gam family protein | - |
| EP54_RS10370 | 2037666..2037902 | - | 237 | WP_047335186.1 | hypothetical protein | - |
| EP54_RS10375 | 2037910..2038170 | - | 261 | WP_000291075.1 | DUF1108 family protein | - |
| EP54_RS10380 | 2038264..2038584 | - | 321 | WP_000219666.1 | hypothetical protein | - |
| EP54_RS16255 | 2038585..2038752 | - | 168 | WP_047335187.1 | DUF1270 domain-containing protein | - |
| EP54_RS10390 | 2038745..2038960 | - | 216 | WP_025175692.1 | hypothetical protein | - |
| EP54_RS10395 | 2039031..2039696 | + | 666 | WP_031764600.1 | hypothetical protein | - |
| EP54_RS10400 | 2039801..2040550 | - | 750 | WP_001148587.1 | phage antirepressor KilAC domain-containing protein | - |
| EP54_RS10405 | 2040552..2040737 | - | 186 | WP_000933365.1 | helix-turn-helix transcriptional regulator | - |
| EP54_RS10410 | 2041311..2041514 | - | 204 | WP_031764597.1 | hypothetical protein | - |
| EP54_RS10415 | 2041528..2041764 | - | 237 | WP_001121116.1 | helix-turn-helix domain-containing protein | - |
| EP54_RS10420 | 2041915..2042229 | + | 315 | WP_000333630.1 | helix-turn-helix domain-containing protein | Antitoxin |
| EP54_RS10425 | 2042242..2042703 | + | 462 | WP_001573840.1 | phage protein | Toxin |
| EP54_RS10435 | 2042887..2043408 | + | 522 | WP_001102444.1 | hypothetical protein | - |
| EP54_RS10440 | 2043401..2043871 | + | 471 | WP_000183249.1 | hypothetical protein | - |
| EP54_RS10445 | 2043941..2044987 | + | 1047 | WP_001145732.1 | site-specific integrase | - |
| EP54_RS10450 | 2045032..2046177 | + | 1146 | WP_001245448.1 | radical SAM/CxCxxxxC motif protein YfkAB | - |
| EP54_RS10455 | 2046437..2046967 | - | 531 | WP_000184383.1 | acyl-CoA thioesterase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2000279..2044987 | 44708 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18060.43 Da Isoelectric Point: 4.6915
>T46825 WP_001573840.1 NZ_CP007670:2042242-2042703 [Staphylococcus aureus]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T46825 NZ_CP007670:2042242-2042703 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAGTAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAGGCAGGAATTCTCTTCGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCTGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCACGT
AGACACGGCTTTATCTCAGCAGTCCCTTTACGTGAAATTGTAGAAGCATACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATACAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACATTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAGTAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAGGCAGGAATTCTCTTCGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCTGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCACGT
AGACACGGCTTTATCTCAGCAGTCCCTTTACGTGAAATTGTAGAAGCATACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATACAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACATTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12063.56 Da Isoelectric Point: 6.4736
>AT46825 WP_000333630.1 NZ_CP007670:2041915-2042229 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
Download Length: 315 bp
>AT46825 NZ_CP007670:2041915-2042229 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGCGGAAATATCAAAAATCTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCGTATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCATCTT
GAAGGAGAATTGACAGATGACGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAAGTAA
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGCGGAAATATCAAAAATCTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCGTATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCATCTT
GAAGGAGAATTGACAGATGACGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2C9TYR5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E7YIA0 |