Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 878244..878721 Replicon chromosome
Accession NZ_CP007670
Organism Staphylococcus aureus strain M121

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag EP54_RS04310 Protein ID WP_000052078.1
Coordinates 878244..878432 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag EP54_RS04315 Protein ID WP_001059690.1
Coordinates 878461..878721 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EP54_RS04280 874285..874755 + 471 WP_000824472.1 hypothetical protein -
EP54_RS04285 875096..875782 + 687 WP_001548082.1 thermonuclease family protein -
EP54_RS04290 876139..876339 + 201 WP_001059082.1 cold-shock protein -
EP54_RS04295 876835..877053 - 219 WP_000005886.1 hypothetical protein -
EP54_RS04300 877115..877399 - 285 WP_001004395.1 hypothetical protein -
EP54_RS04305 877487..878056 - 570 WP_001106654.1 hypothetical protein -
EP54_RS04310 878244..878432 - 189 WP_000052078.1 hypothetical protein Toxin
EP54_RS04315 878461..878721 - 261 WP_001059690.1 hypothetical protein Antitoxin
EP54_RS04320 879062..879265 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
EP54_RS04325 879262..879498 - 237 WP_000368687.1 hypothetical protein -
EP54_RS04330 879723..880304 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
EP54_RS04335 880377..880994 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
EP54_RS04340 881149..881643 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
EP54_RS04345 882042..882464 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
EP54_RS04350 882612..883328 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T46821 WP_000052078.1 NZ_CP007670:c878432-878244 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T46821 NZ_CP007670:c878432-878244 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT46821 WP_001059690.1 NZ_CP007670:c878721-878461 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT46821 NZ_CP007670:c878721-878461 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References