46820

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 413758..414275 Replicon chromosome
Accession NZ_CP007670
Organism Staphylococcus aureus strain M121

Toxin (Protein)


Gene name TscT Uniprot ID A0A2C9TUQ6
Locus tag EP54_RS01955 Protein ID WP_033863183.1
Coordinates 413970..414275 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A2B8BQK3
Locus tag EP54_RS01950 Protein ID WP_001058490.1
Coordinates 413758..413967 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EP54_RS01910 409161..409403 + 243 WP_000897044.1 30S ribosomal protein S18 -
EP54_RS01915 409618..410607 - 990 WP_047335133.1 Abi family protein -
EP54_RS01920 410613..411827 - 1215 WP_047335134.1 site-specific integrase -
EP54_RS15080 411853..412776 - 924 WP_048568940.1 helix-turn-helix domain-containing protein -
EP54_RS01930 412883..413083 + 201 WP_001033058.1 helix-turn-helix domain-containing protein -
EP54_RS01935 413122..413334 + 213 WP_033863184.1 helix-turn-helix transcriptional regulator -
EP54_RS01940 413335..413607 + 273 WP_001138301.1 helix-turn-helix domain-containing protein -
EP54_RS01945 413619..413765 + 147 WP_000784873.1 hypothetical protein -
EP54_RS01950 413758..413967 + 210 WP_001058490.1 hypothetical protein Antitoxin
EP54_RS01955 413970..414275 + 306 WP_033863183.1 DUF1474 family protein Toxin
EP54_RS01960 414350..415963 + 1614 WP_047335135.1 hypothetical protein -
EP54_RS01965 416134..416937 + 804 WP_033863177.1 bifunctional DNA primase/polymerase -
EP54_RS01970 416924..417196 + 273 WP_001149387.1 hypothetical protein -
EP54_RS01975 417198..417839 + 642 WP_047335136.1 pathogenicity island protein -
EP54_RS01980 418546..418890 + 345 WP_001288441.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 408606..428032 19426


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 12172.46 Da        Isoelectric Point: 4.4054

>T46820 WP_033863183.1 NZ_CP007670:413970-414275 [Staphylococcus aureus]
MNLEIKDLFSDLKLLKDRFEDLKDNHGWHFEELYPHEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSDVSLATESDDA

Download         Length: 306 bp

>T46820 NZ_CP007670:413970-414275 [Staphylococcus aureus]
ATGAATTTGGAAATTAAAGATTTGTTTAGCGATTTGAAATTGTTGAAAGATAGATTCGAAGATTTAAAGGATAATCATGG
TTGGCATTTTGAGGAGCTATATCCACATGAACCAAATCATGTCTTAAATAAAGATGAATTAATTGGAGAGGGATTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTATGAAATAGAAAAAGCATCATCTGATGTAAGTTTGGCGACAGAATCAGATGACGCATAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8153.17 Da        Isoelectric Point: 4.3591

>AT46820 WP_001058490.1 NZ_CP007670:413758-413967 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVDGIEVVSEVSREKHLELIMKWCAQELKNNFQLGKGE

Download         Length: 210 bp

>AT46820 NZ_CP007670:413758-413967 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGGTTAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGGAAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TUQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A2B8BQK3

References