Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1050271..1050893 Replicon chromosome
Accession NZ_CP007669
Organism Moraxella catarrhalis strain ATCC 25239

Toxin (Protein)


Gene name hicA Uniprot ID A0A1E9VU27
Locus tag MC25239_RS04830 Protein ID WP_003660025.1
Coordinates 1050711..1050893 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1E9VTZ2
Locus tag MC25239_RS04825 Protein ID WP_003660026.1
Coordinates 1050271..1050678 (-) Length 136 a.a.

Genomic Context


MC25239_RS04800MC25239_RS04805MC25239_RS04810MC25239_RS04820MC25239_RS04835MC25239_RS04840MC25239_RS04815MC25239_RS04825MC25239_RS04830MC25239_RS04845MC25239_RS04850MC25239_RS04855
Location: 1047332..1047661 (330 bp)
Type: Others
Protein ID: WP_080743067.1
Location: 1047770..1048159 (390 bp)
Type: Others
Protein ID: WP_042510346.1
Location: 1048243..1048914 (672 bp)
Type: Others
Protein ID: WP_042510347.1
Location: 1049497..1050279 (783 bp)
Type: Others
Protein ID: WP_042510348.1
Location: 1050993..1051316 (324 bp)
Type: Others
Protein ID: Protein_932
Location: 1051319..1051546 (228 bp)
Type: Others
Protein ID: WP_003659817.1
Location: 1048911..1049114 (204 bp)
Type: Others
Protein ID: WP_003660029.1
Location: 1050271..1050678 (408 bp)
Type: Antitoxin
Protein ID: WP_003660026.1
Location: 1050711..1050893 (183 bp)
Type: Toxin
Protein ID: WP_003660025.1
Location: 1051959..1053059 (1101 bp)
Type: Others
Protein ID: WP_042510350.1
Location: 1053059..1054237 (1179 bp)
Type: Others
Protein ID: WP_042510351.1
Location: 1054265..1055428 (1164 bp)
Type: Others
Protein ID: WP_042510352.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MC25239_RS048001047332..1047661+330WP_080743067.1phage tail protein-
MC25239_RS048051047770..1048159+390WP_042510346.1hypothetical protein-
MC25239_RS048101048243..1048914+672WP_042510347.1phage minor tail protein L-
MC25239_RS048151048911..1049114-204WP_003660029.1hypothetical protein-
MC25239_RS048201049497..1050279+783WP_042510348.1C40 family peptidase-
MC25239_RS048251050271..1050678-408WP_003660026.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
MC25239_RS048301050711..1050893-183WP_003660025.1type II toxin-antitoxin system HicA family toxinToxin
MC25239_RS048351050993..1051316+324Protein_932tail assembly protein-
MC25239_RS048401051319..1051546+228WP_003659817.1hypothetical protein-
MC25239_RS048451051959..1053059-1101WP_042510350.1ABC transporter permease-
MC25239_RS048501053059..1054237-1179WP_042510351.1ABC transporter permease-
MC25239_RS048551054265..1055428-1164WP_042510352.1biotin/lipoyl-binding protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--1030952..105131920367


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 61 a.a.        Molecular weight: 6813.95 Da        Isoelectric Point: 10.6682

>T46819 WP_003660025.1 NZ_CP007669:c1050893-1050711 [Moraxella catarrhalis]
MNSRQMIKLITDDGWYEVAVRGSHHHYKHPTKQGKVTIPHPKSDLPIGTVKQILKQAGLK

Download         Length: 183 bp

>T46819 NZ_CP007669:c1050893-1050711 [Moraxella catarrhalis]
ATGAATAGCCGTCAAATGATTAAGCTAATCACTGATGACGGTTGGTATGAAGTTGCGGTGCGTGGCAGTCATCATCACTA
CAAACACCCAACCAAACAGGGCAAGGTAACCATACCTCACCCCAAGTCAGACTTACCAATCGGCACAGTTAAGCAAATCT
TAAAACAAGCTGGGTTAAAATAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14907.99 Da        Isoelectric Point: 4.4954

>AT46819 WP_003660026.1 NZ_CP007669:c1050678-1050271 [Moraxella catarrhalis]
MLYPIAIEKPVSTNECYGVIVPDIVGCFSAGDTVDEAVKNAYEAIVLHLDMLADDGEDIPQATDIAHHQENPDYQGMIWA
VVDIDLSAYMGKSEKINVTLPSRLIVKIDEKVKAHKSLYKSRSNYLAQLASRDLA

Download         Length: 408 bp

>AT46819 NZ_CP007669:c1050678-1050271 [Moraxella catarrhalis]
ATGTTATATCCTATCGCTATTGAAAAGCCCGTCAGCACCAATGAGTGTTATGGCGTGATTGTACCTGATATTGTAGGCTG
TTTTAGTGCAGGCGATACAGTAGATGAGGCGGTTAAAAATGCCTATGAAGCCATTGTTTTACATTTGGATATGTTGGCTG
ATGATGGTGAGGATATCCCTCAAGCGACCGATATTGCTCATCATCAAGAAAATCCTGATTATCAAGGTATGATTTGGGCG
GTGGTTGATATTGATTTATCCGCCTATATGGGCAAATCTGAAAAGATTAATGTTACCTTGCCAAGTCGCTTGATTGTCAA
AATTGACGAAAAGGTTAAAGCACACAAATCGCTATATAAGAGTCGTAGTAATTACCTAGCACAGCTTGCCAGTCGTGATT
TAGCCTAG

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A1E9VU27


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1E9VTZ2

References