Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 1050271..1050893 | Replicon | chromosome |
Accession | NZ_CP007669 | ||
Organism | Moraxella catarrhalis strain ATCC 25239 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | A0A1E9VU27 |
Locus tag | MC25239_RS04830 | Protein ID | WP_003660025.1 |
Coordinates | 1050711..1050893 (-) | Length | 61 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | A0A1E9VTZ2 |
Locus tag | MC25239_RS04825 | Protein ID | WP_003660026.1 |
Coordinates | 1050271..1050678 (-) | Length | 136 a.a. |
Genomic Context
Location: 1047332..1047661 (330 bp)
Type: Others
Protein ID: WP_080743067.1
Type: Others
Protein ID: WP_080743067.1
Location: 1047770..1048159 (390 bp)
Type: Others
Protein ID: WP_042510346.1
Type: Others
Protein ID: WP_042510346.1
Location: 1048243..1048914 (672 bp)
Type: Others
Protein ID: WP_042510347.1
Type: Others
Protein ID: WP_042510347.1
Location: 1049497..1050279 (783 bp)
Type: Others
Protein ID: WP_042510348.1
Type: Others
Protein ID: WP_042510348.1
Location: 1050993..1051316 (324 bp)
Type: Others
Protein ID: Protein_932
Type: Others
Protein ID: Protein_932
Location: 1051319..1051546 (228 bp)
Type: Others
Protein ID: WP_003659817.1
Type: Others
Protein ID: WP_003659817.1
Location: 1048911..1049114 (204 bp)
Type: Others
Protein ID: WP_003660029.1
Type: Others
Protein ID: WP_003660029.1
Location: 1050271..1050678 (408 bp)
Type: Antitoxin
Protein ID: WP_003660026.1
Type: Antitoxin
Protein ID: WP_003660026.1
Location: 1050711..1050893 (183 bp)
Type: Toxin
Protein ID: WP_003660025.1
Type: Toxin
Protein ID: WP_003660025.1
Location: 1051959..1053059 (1101 bp)
Type: Others
Protein ID: WP_042510350.1
Type: Others
Protein ID: WP_042510350.1
Location: 1053059..1054237 (1179 bp)
Type: Others
Protein ID: WP_042510351.1
Type: Others
Protein ID: WP_042510351.1
Location: 1054265..1055428 (1164 bp)
Type: Others
Protein ID: WP_042510352.1
Type: Others
Protein ID: WP_042510352.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MC25239_RS04800 | 1047332..1047661 | + | 330 | WP_080743067.1 | phage tail protein | - |
MC25239_RS04805 | 1047770..1048159 | + | 390 | WP_042510346.1 | hypothetical protein | - |
MC25239_RS04810 | 1048243..1048914 | + | 672 | WP_042510347.1 | phage minor tail protein L | - |
MC25239_RS04815 | 1048911..1049114 | - | 204 | WP_003660029.1 | hypothetical protein | - |
MC25239_RS04820 | 1049497..1050279 | + | 783 | WP_042510348.1 | C40 family peptidase | - |
MC25239_RS04825 | 1050271..1050678 | - | 408 | WP_003660026.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
MC25239_RS04830 | 1050711..1050893 | - | 183 | WP_003660025.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
MC25239_RS04835 | 1050993..1051316 | + | 324 | Protein_932 | tail assembly protein | - |
MC25239_RS04840 | 1051319..1051546 | + | 228 | WP_003659817.1 | hypothetical protein | - |
MC25239_RS04845 | 1051959..1053059 | - | 1101 | WP_042510350.1 | ABC transporter permease | - |
MC25239_RS04850 | 1053059..1054237 | - | 1179 | WP_042510351.1 | ABC transporter permease | - |
MC25239_RS04855 | 1054265..1055428 | - | 1164 | WP_042510352.1 | biotin/lipoyl-binding protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 1030952..1051319 | 20367 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6813.95 Da Isoelectric Point: 10.6682
>T46819 WP_003660025.1 NZ_CP007669:c1050893-1050711 [Moraxella catarrhalis]
MNSRQMIKLITDDGWYEVAVRGSHHHYKHPTKQGKVTIPHPKSDLPIGTVKQILKQAGLK
MNSRQMIKLITDDGWYEVAVRGSHHHYKHPTKQGKVTIPHPKSDLPIGTVKQILKQAGLK
Download Length: 183 bp
>T46819 NZ_CP007669:c1050893-1050711 [Moraxella catarrhalis]
ATGAATAGCCGTCAAATGATTAAGCTAATCACTGATGACGGTTGGTATGAAGTTGCGGTGCGTGGCAGTCATCATCACTA
CAAACACCCAACCAAACAGGGCAAGGTAACCATACCTCACCCCAAGTCAGACTTACCAATCGGCACAGTTAAGCAAATCT
TAAAACAAGCTGGGTTAAAATAA
ATGAATAGCCGTCAAATGATTAAGCTAATCACTGATGACGGTTGGTATGAAGTTGCGGTGCGTGGCAGTCATCATCACTA
CAAACACCCAACCAAACAGGGCAAGGTAACCATACCTCACCCCAAGTCAGACTTACCAATCGGCACAGTTAAGCAAATCT
TAAAACAAGCTGGGTTAAAATAA
Antitoxin
Download Length: 136 a.a. Molecular weight: 14907.99 Da Isoelectric Point: 4.4954
>AT46819 WP_003660026.1 NZ_CP007669:c1050678-1050271 [Moraxella catarrhalis]
MLYPIAIEKPVSTNECYGVIVPDIVGCFSAGDTVDEAVKNAYEAIVLHLDMLADDGEDIPQATDIAHHQENPDYQGMIWA
VVDIDLSAYMGKSEKINVTLPSRLIVKIDEKVKAHKSLYKSRSNYLAQLASRDLA
MLYPIAIEKPVSTNECYGVIVPDIVGCFSAGDTVDEAVKNAYEAIVLHLDMLADDGEDIPQATDIAHHQENPDYQGMIWA
VVDIDLSAYMGKSEKINVTLPSRLIVKIDEKVKAHKSLYKSRSNYLAQLASRDLA
Download Length: 408 bp
>AT46819 NZ_CP007669:c1050678-1050271 [Moraxella catarrhalis]
ATGTTATATCCTATCGCTATTGAAAAGCCCGTCAGCACCAATGAGTGTTATGGCGTGATTGTACCTGATATTGTAGGCTG
TTTTAGTGCAGGCGATACAGTAGATGAGGCGGTTAAAAATGCCTATGAAGCCATTGTTTTACATTTGGATATGTTGGCTG
ATGATGGTGAGGATATCCCTCAAGCGACCGATATTGCTCATCATCAAGAAAATCCTGATTATCAAGGTATGATTTGGGCG
GTGGTTGATATTGATTTATCCGCCTATATGGGCAAATCTGAAAAGATTAATGTTACCTTGCCAAGTCGCTTGATTGTCAA
AATTGACGAAAAGGTTAAAGCACACAAATCGCTATATAAGAGTCGTAGTAATTACCTAGCACAGCTTGCCAGTCGTGATT
TAGCCTAG
ATGTTATATCCTATCGCTATTGAAAAGCCCGTCAGCACCAATGAGTGTTATGGCGTGATTGTACCTGATATTGTAGGCTG
TTTTAGTGCAGGCGATACAGTAGATGAGGCGGTTAAAAATGCCTATGAAGCCATTGTTTTACATTTGGATATGTTGGCTG
ATGATGGTGAGGATATCCCTCAAGCGACCGATATTGCTCATCATCAAGAAAATCCTGATTATCAAGGTATGATTTGGGCG
GTGGTTGATATTGATTTATCCGCCTATATGGGCAAATCTGAAAAGATTAATGTTACCTTGCCAAGTCGCTTGATTGTCAA
AATTGACGAAAAGGTTAAAGCACACAAATCGCTATATAAGAGTCGTAGTAATTACCTAGCACAGCTTGCCAGTCGTGATT
TAGCCTAG
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1E9VU27 |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1E9VTZ2 |