Detailed information of TA system TA046816

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 1189254..1190229
• Replicon: chromosome
• Accession: NZ_CP007666
• Organism: Bacillus anthracis str. Vollum

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: A0A2R2IKP2
• Locus tag: DJ46_RS07680
• Protein ID: WP_002036394.1
• Coordinates: 1189254..1189991 (+)
• Length: 246 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: R8HWP4
• Locus tag: DJ46_RS07685
• Protein ID: WP_000588712.1
• Coordinates: 1190104..1190229 (+)
• Length: 42 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DJ46_RS07660	1184982..1185764	+	783	WP_000381787.1	class I SAM-dependent methyltransferase	-
DJ46_RS07665	1185886..1187571	-	1686	WP_014654562.1	alpha-keto acid decarboxylase family protein	-
DJ46_RS07670	1187678..1188160	+	483	WP_000191911.1	MarR family winged helix-turn-helix transcriptional regulator	-
DJ46_RS07675	1188328..1189065	+	738	WP_000594139.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
DJ46_RS07680	1189254..1189991	+	738	WP_002036394.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
DJ46_RS07685	1190104..1190229	+	126	WP_000588712.1	hypothetical protein	Antitoxin
DJ46_RS32010	1190306..1190482	+	177	WP_000852614.1	hypothetical protein	-
DJ46_RS07695	1190519..1190800	-	282	WP_001041555.1	hypothetical protein	-
DJ46_RS07700	1191077..1191313	-	237	WP_001021689.1	hypothetical protein	-
DJ46_RS32015	1191652..1191828	+	177	WP_000808045.1	hypothetical protein	-
DJ46_RS07710	1191972..1193441	+	1470	WP_000287522.1	beta-Ala-His dipeptidase	-
DJ46_RS07715	1194005..1194475	-	471	WP_000670597.1	DUF5065 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (9-243)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 246 a.a.
• Molecular weight: 28373.03 Da
• Isoelectric Point: 8.2705

>T46816 WP_002036394.1 NZ_CP007666:1189254-1189991 [Bacillus anthracis str. Vollum]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Nucleotide

• Length: 738 bp

>T46816 NZ_CP007666:1189254-1189991 [Bacillus anthracis str. Vollum]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTTCTTGTTTTCTTTTACTGGAGAAATGA
AGAATTGTATGAGGAGAAGAAGCAACGAATTAGAAAGACTTGGTATGGGTTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 42 a.a.
• Molecular weight: 4938.34 Da
• Isoelectric Point: 3.9150

>AT46816 WP_000588712.1 NZ_CP007666:1190104-1190229 [Bacillus anthracis str. Vollum]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Nucleotide

• Length: 126 bp

>AT46816 NZ_CP007666:1190104-1190229 [Bacillus anthracis str. Vollum]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Structures

Toxin

• AlphaFold DB: A0A2R2IKP2

Antitoxin

• AlphaFold DB: A0A366GQT1