Detailed information of TA system TA046808

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 2184817..2185331
• Replicon: chromosome
• Accession: NZ_CP007659
• Organism: Staphylococcus aureus strain H-EMRSA-15

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: T1YA99
• Locus tag: ER16_RS11055
• Protein ID: WP_000581792.1
• Coordinates: 2184817..2185026 (-)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: -
• Locus tag: ER16_RS11060
• Protein ID: WP_000138928.1
• Coordinates: 2185038..2185331 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ER16_RS11035	2180325..2181683	-	1359	WP_000611469.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-
ER16_RS11040	2181698..2182768	-	1071	WP_000159632.1	D-alanine--D-alanine ligase	-
ER16_RS11045	2183086..2184288	+	1203	WP_001109944.1	rod shape-determining protein RodA	-
ER16_RS11050	2184552..2184689	-	138	WP_000828354.1	hypothetical protein	-
ER16_RS11055	2184817..2185026	-	210	WP_000581792.1	heavy-metal-associated domain-containing protein	Toxin
ER16_RS11060	2185038..2185331	-	294	WP_000138928.1	copper-sensing transcriptional repressor CsoR	Antitoxin
ER16_RS11065	2185497..2186981	+	1485	WP_000571551.1	cardiolipin synthase	-
ER16_RS11070	2187009..2187656	+	648	WP_001187617.1	HD domain-containing protein	-
ER16_RS11075	2188134..2189006	-	873	WP_000725802.1	membrane protein insertase YidC	-
ER16_RS11080	2189092..2189733	-	642	WP_000483153.1	thiamine phosphate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (23-66)

Antitoxin

• Metal-sensitive transcriptional repressor (14-92)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7843.77 Da
• Isoelectric Point: 4.1008

>T46808 WP_000581792.1 NZ_CP007659:c2185026-2184817 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Nucleotide

• Length: 210 bp

>T46808 NZ_CP007659:c2185026-2184817 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGACGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11184.82 Da
• Isoelectric Point: 6.2243

>AT46808 WP_000138928.1 NZ_CP007659:c2185331-2185038 [Staphylococcus aureus]
MTEQDIAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Nucleotide

• Length: 294 bp

>AT46808 NZ_CP007659:c2185331-2185038 [Staphylococcus aureus]
ATGACTGAACAAGATATTGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Structures

Toxin

• PDB: 6FF1