Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2165061..2165590 Replicon chromosome
Accession NZ_CP007659
Organism Staphylococcus aureus strain H-EMRSA-15

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ER16_RS10965 Protein ID WP_000621175.1
Coordinates 2165061..2165423 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag ER16_RS10970 Protein ID WP_000948330.1
Coordinates 2165420..2165590 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ER16_RS10940 2162039..2162809 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
ER16_RS10945 2162784..2163263 - 480 WP_001190825.1 anti-sigma B factor RsbW -
ER16_RS10950 2163265..2163591 - 327 WP_001052491.1 anti-sigma factor antagonist -
ER16_RS10955 2163711..2164712 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
ER16_RS10965 2165061..2165423 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ER16_RS10970 2165420..2165590 - 171 WP_000948330.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
ER16_RS10975 2165675..2166823 - 1149 WP_001281141.1 alanine racemase -
ER16_RS10980 2166889..2167248 - 360 WP_000581193.1 holo-ACP synthase -
ER16_RS10985 2167252..2167743 - 492 WP_001205918.1 PH domain-containing protein -
ER16_RS10990 2167730..2169313 - 1584 WP_001294624.1 PH domain-containing protein -
ER16_RS10995 2169306..2169785 - 480 WP_001287080.1 hypothetical protein -
ER16_RS11000 2169994..2170554 - 561 WP_001092400.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T46807 WP_000621175.1 NZ_CP007659:c2165423-2165061 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T46807 NZ_CP007659:c2165423-2165061 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATTATTCAAAATGACACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAATATAAATTGGATAAAGACTCAGTCATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTATTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6237.75 Da        Isoelectric Point: 3.8305

>AT46807 WP_000948330.1 NZ_CP007659:c2165590-2165420 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNESYLSSNSTNE

Download         Length: 171 bp

>AT46807 NZ_CP007659:c2165590-2165420 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAATCATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References