46795

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 847389..847866 Replicon chromosome
Accession NZ_CP007659
Organism Staphylococcus aureus strain H-EMRSA-15

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag ER16_RS04015 Protein ID WP_000052076.1
Coordinates 847389..847577 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag ER16_RS04020 Protein ID WP_001059690.1
Coordinates 847606..847866 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ER16_RS03985 843379..843900 + 522 WP_000824488.1 hypothetical protein -
ER16_RS03990 844241..844927 + 687 WP_001670297.1 thermonuclease family protein -
ER16_RS03995 845284..845484 + 201 WP_001059082.1 cold-shock protein -
ER16_RS04000 845980..846198 - 219 WP_000005876.1 hypothetical protein -
ER16_RS04005 846260..846544 - 285 WP_001004395.1 hypothetical protein -
ER16_RS04010 846632..847201 - 570 WP_001106646.1 hypothetical protein -
ER16_RS04015 847389..847577 - 189 WP_000052076.1 hypothetical protein Toxin
ER16_RS04020 847606..847866 - 261 WP_001059690.1 hypothetical protein Antitoxin
ER16_RS04025 848206..848409 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
ER16_RS04030 848406..848642 - 237 WP_000368687.1 hypothetical protein -
ER16_RS04035 848867..849448 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
ER16_RS04040 849521..850138 - 618 WP_000255559.1 LysE/ArgO family amino acid transporter -
ER16_RS04045 850292..850786 - 495 WP_000590539.1 GNAT family N-acetyltransferase -
ER16_RS04050 851185..851607 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
ER16_RS04055 851755..852471 + 717 WP_000150015.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T46795 WP_000052076.1 NZ_CP007659:c847577-847389 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T46795 NZ_CP007659:c847577-847389 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTTACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT46795 WP_001059690.1 NZ_CP007659:c847866-847606 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT46795 NZ_CP007659:c847866-847606 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References