Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 865357..865834 Replicon chromosome
Accession NZ_CP007657
Organism Staphylococcus aureus strain V2200

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag EP20_RS04185 Protein ID WP_000052078.1
Coordinates 865357..865545 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag EP20_RS04190 Protein ID WP_001059690.1
Coordinates 865574..865834 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EP20_RS04155 861398..861868 + 471 WP_000824471.1 hypothetical protein -
EP20_RS04160 862209..862895 + 687 WP_001548082.1 thermonuclease family protein -
EP20_RS04165 863252..863452 + 201 WP_001059082.1 cold-shock protein -
EP20_RS04170 863948..864166 - 219 WP_000005886.1 hypothetical protein -
EP20_RS04175 864228..864512 - 285 WP_001004395.1 hypothetical protein -
EP20_RS04180 864600..865169 - 570 WP_001106654.1 hypothetical protein -
EP20_RS04185 865357..865545 - 189 WP_000052078.1 hypothetical protein Toxin
EP20_RS04190 865574..865834 - 261 WP_001059690.1 hypothetical protein Antitoxin
EP20_RS04195 866175..866378 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
EP20_RS04200 866375..866611 - 237 WP_000368687.1 hypothetical protein -
EP20_RS04205 866836..867417 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
EP20_RS04210 867490..868107 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
EP20_RS04215 868262..868756 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
EP20_RS04220 869155..869577 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
EP20_RS04225 869725..870441 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-62)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T46781 WP_000052078.1 NZ_CP007657:c865545-865357 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T46781 NZ_CP007657:c865545-865357 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT46781 WP_001059690.1 NZ_CP007657:c865834-865574 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT46781 NZ_CP007657:c865834-865574 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References