Detailed information of TA system TA046780

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Txe-Axe/YoeB-RelB
• Location: 94089..94599
• Replicon: plasmid pLMP1046
• Accession: NZ_CP007649
• Organism: Ligilactobacillus salivarius strain JCM1046

Toxin (Protein)

• Gene name: Txe
• Uniprot ID: -
• Locus tag: LSJ_RS11345
• Protein ID: WP_044006010.1
• Coordinates: 94348..94599 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: Axe
• Uniprot ID: -
• Locus tag: LSJ_RS11340
• Protein ID: WP_044006009.1
• Coordinates: 94089..94355 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LSJ_RS11305	89781..91007	+	1227	WP_080739411.1	RepB family plasmid replication initiator protein	-
LSJ_RS11310	91221..91565	+	345	WP_044006003.1	hypothetical protein	-
LSJ_RS11315	91585..91827	+	243	WP_044006004.1	hypothetical protein	-
LSJ_RS11320	91966..92325	+	360	WP_044006005.1	hypothetical protein	-
LSJ_RS11325	92473..92808	+	336	WP_044006006.1	hypothetical protein	-
LSJ_RS11335	93659..93994	+	336	WP_044006008.1	hypothetical protein	-
LSJ_RS11340	94089..94355	+	267	WP_044006009.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LSJ_RS11345	94348..94599	+	252	WP_044006010.1	Txe/YoeB family addiction module toxin	Toxin
LSJ_RS11350	95052..96158	-	1107	WP_044006011.1	hypothetical protein	-
LSJ_RS11355	96474..97571	+	1098	WP_044006012.1	ParM/StbA family protein	-
LSJ_RS11360	97580..97978	+	399	WP_044006013.1	hypothetical protein	-
LSJ_RS11365	98422..99273	+	852	WP_044006014.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..101883	101883

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-55)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 10098.41 Da
• Isoelectric Point: 8.4252

>T46780 WP_044006010.1 NZ_CP007649:94348-94599 [Ligilactobacillus salivarius]
MNKNWSDEAWDDYMSWQSDKRIVKKINKLIKDIDRHPFSGIGKPEPLKYGLSGTWSRRITEEHRIVYEIKDDEIRIYSVR
DHY

Nucleotide

• Length: 252 bp

>T46780 NZ_CP007649:94348-94599 [Ligilactobacillus salivarius]
ATGAATAAGAATTGGTCTGATGAAGCCTGGGATGACTACATGAGCTGGCAAAGCGATAAAAGAATAGTTAAGAAAATTAA
TAAGCTAATAAAAGATATTGATAGACATCCTTTTTCAGGAATAGGTAAACCAGAACCGTTAAAATATGGTTTATCAGGAA
CATGGTCTAGAAGAATTACGGAAGAGCATCGAATAGTCTATGAGATAAAAGATGATGAGATACGTATCTATTCTGTCAGA
GACCATTATTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10412.63 Da
• Isoelectric Point: 4.5967

>AT46780 WP_044006009.1 NZ_CP007649:94089-94355 [Ligilactobacillus salivarius]
MEATTYSNFRKSLKSFMKQVNEDSEPLIVTNKNKEEDIVVMGKDDYDSLVETMRIIENKYLYNKIRRGREQLDSKSNYHD
LIEVDGDE

Nucleotide

• Length: 267 bp

>AT46780 NZ_CP007649:94089-94355 [Ligilactobacillus salivarius]
ATGGAAGCTACAACATACTCTAATTTTAGAAAATCCCTTAAATCATTCATGAAGCAAGTCAATGAAGATTCAGAACCATT
AATTGTTACTAATAAAAATAAAGAAGAAGATATTGTTGTTATGGGTAAAGATGACTATGATTCGCTAGTCGAAACCATGA
GAATTATAGAAAATAAATATCTCTATAACAAGATAAGACGTGGCAGAGAACAATTAGATTCTAAAAGTAACTACCACGAT
TTAATCGAGGTTGATGGCGATGAATAA