Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 217312..217919 Replicon plasmid pRetIE4803d
Accession NZ_CP007645
Organism Rhizobium etli bv. phaseoli str. IE4803

Toxin (Protein)


Gene name hicA Uniprot ID A0A7W8XHT1
Locus tag IE4803_RS30555 Protein ID WP_010053144.1
Coordinates 217665..217919 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7U4IXI5
Locus tag IE4803_RS30550 Protein ID WP_040112694.1
Coordinates 217312..217668 (-) Length 119 a.a.

Genomic Context

IE4803_RS30530IE4803_RS30535IE4803_RS30540IE4803_RS30545IE4803_RS30560IE4803_RS30565IE4803_RS30570IE4803_RS30575IE4803_RS30580IE4803_RS30550IE4803_RS30555
Location: 214750..215139 (390 bp)
Type: Others
Protein ID: WP_040112721.1
Location: 215136..216383 (1248 bp)
Type: Others
Protein ID: WP_040112722.1
Location: 216380..216784 (405 bp)
Type: Others
Protein ID: WP_040112723.1
Location: 216817..217047 (231 bp)
Type: Others
Protein ID: WP_040112724.1
Location: 218965..219303 (339 bp)
Type: Others
Protein ID: WP_194252301.1
Location: 219300..220595 (1296 bp)
Type: Others
Protein ID: WP_194252298.1
Location: 220645..221436 (792 bp)
Type: Others
Protein ID: WP_040112726.1
Location: 221481..222143 (663 bp)
Type: Others
Protein ID: WP_040112727.1
Location: 222140..222799 (660 bp)
Type: Others
Protein ID: WP_040112728.1
Location: 217312..217668 (357 bp)
Type: Antitoxin
Protein ID: WP_040112694.1
Location: 217665..217919 (255 bp)
Type: Toxin
Protein ID: WP_010053144.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IE4803_RS30530214750..215139+390WP_040112721.1response regulator-
IE4803_RS30535215136..216383+1248WP_040112722.1response regulator-
IE4803_RS30540216380..216784+405WP_040112723.1hypothetical protein-
IE4803_RS30545216817..217047+231WP_040112724.1hypothetical protein-
IE4803_RS30550217312..217668-357WP_040112694.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
IE4803_RS30555217665..217919-255WP_010053144.1type II toxin-antitoxin system HicA family toxinToxin
IE4803_RS30560218965..219303+339WP_194252301.1RidA family protein-
IE4803_RS30565219300..220595+1296WP_194252298.1allantoate amidohydrolase-
IE4803_RS30570220645..221436+792WP_040112726.1transporter substrate-binding domain-containing protein-
IE4803_RS30575221481..222143+663WP_040112727.1amino acid ABC transporter permease-
IE4803_RS30580222140..222799+660WP_040112728.1amino acid ABC transporter permease-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideConjugative plasmid--1..742914742914


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9292.69 Da        Isoelectric Point: 10.2030

>T46775 WP_010053144.1 NZ_CP007645:c217919-217665 [Rhizobium etli bv. phaseoli str. IE4803]
MNSKQRKTLAAVFKDPVSGTIEWAAIENLLVAAGADLIEGNGSRVKFEKDGIIASFHRPHPAKEAKRYQVRDAREFLMQI
GVTP

Download         Length: 255 bp

>T46775 NZ_CP007645:c217919-217665 [Rhizobium etli bv. phaseoli str. IE4803]
ATGAACAGCAAGCAGAGAAAGACTCTCGCGGCGGTCTTCAAGGACCCGGTCTCGGGAACCATTGAATGGGCCGCTATAGA
GAATTTGCTTGTGGCTGCCGGAGCCGACCTCATTGAGGGGAACGGTTCCCGCGTTAAGTTTGAAAAAGACGGGATCATTG
CGAGCTTCCATAGACCACATCCGGCCAAGGAAGCAAAGCGCTATCAGGTGCGCGATGCTCGCGAGTTCCTGATGCAGATT
GGAGTAACGCCATGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13287.99 Da        Isoelectric Point: 5.5836

>AT46775 WP_040112694.1 NZ_CP007645:c217668-217312 [Rhizobium etli bv. phaseoli str. IE4803]
MNIMTYNGYHARIEFDAEDDVFFGRIAGISDVIGFHGDSVAELKKAFHEAVDDYLETCRKIGKEPQRPYSGKMMFRVAPE
VHRRAALAAELSGKSLNQWAEEVLEKAADHYAEARLPA

Download         Length: 357 bp

>AT46775 NZ_CP007645:c217668-217312 [Rhizobium etli bv. phaseoli str. IE4803]
ATGAACATCATGACCTACAACGGATATCACGCTCGCATCGAATTCGATGCTGAGGACGATGTGTTTTTCGGCAGGATTGC
AGGTATCTCCGACGTAATCGGCTTTCACGGTGACAGTGTCGCTGAACTCAAGAAAGCCTTCCATGAGGCAGTCGATGACT
ACCTGGAGACCTGCAGGAAAATCGGCAAAGAGCCTCAGCGACCCTATTCCGGGAAGATGATGTTTCGTGTCGCTCCCGAA
GTCCATCGCCGAGCAGCTCTTGCTGCTGAGCTTTCGGGAAAGAGTCTGAACCAGTGGGCAGAAGAGGTGCTGGAAAAGGC
CGCCGACCATTATGCCGAGGCGCGCTTGCCGGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7W8XHT1

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7U4IXI5

References