Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3047625..3048298 Replicon chromosome
Accession NZ_CP007641
Organism Rhizobium etli bv. phaseoli str. IE4803

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4L6N3
Locus tag IE4803_RS14770 Protein ID WP_039620969.1
Coordinates 3047625..3048038 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A7U4IRJ9
Locus tag IE4803_RS14775 Protein ID WP_039620971.1
Coordinates 3048035..3048298 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IE4803_RS14760 3045117..3046316 - 1200 WP_039620964.1 efflux RND transporter periplasmic adaptor subunit -
IE4803_RS14765 3046591..3047502 - 912 WP_039620966.1 adenylate/guanylate cyclase domain-containing protein -
IE4803_RS14770 3047625..3048038 - 414 WP_039620969.1 type II toxin-antitoxin system VapC family toxin Toxin
IE4803_RS14775 3048035..3048298 - 264 WP_039620971.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
IE4803_RS14780 3048377..3049927 - 1551 WP_039620973.1 SpoVR family protein -
IE4803_RS14785 3049924..3051198 - 1275 WP_038690084.1 YeaH/YhbH family protein -
IE4803_RS14790 3051211..3053154 - 1944 WP_038690085.1 PrkA family serine protein kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(9-57)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15165.61 Da        Isoelectric Point: 7.2779

>T46770 WP_039620969.1 NZ_CP007641:c3048038-3047625 [Rhizobium etli bv. phaseoli str. IE4803]
MTAWMLDTNIASHVIKGDRPEILKRLAAFPMDEIVISSITEGELLYGLAKRGYPKALSERVRQFLLRVDVLPWDHDVTRT
YGDLRAACEAKGTILAPLDMMIAAHAVATAATLVTRDKAFARISEPLKVDDWTGGRS

Download         Length: 414 bp

>T46770 NZ_CP007641:c3048038-3047625 [Rhizobium etli bv. phaseoli str. IE4803]
ATGACGGCATGGATGCTGGACACCAATATCGCCAGTCATGTCATCAAAGGCGATCGGCCGGAGATACTTAAAAGACTGGC
GGCGTTTCCAATGGACGAGATCGTCATCTCATCGATCACGGAAGGGGAATTGCTCTACGGTCTTGCCAAGCGAGGCTATC
CGAAGGCGCTATCCGAGCGGGTAAGGCAATTCCTTCTCAGGGTCGATGTTCTCCCCTGGGATCACGACGTCACGCGAACC
TATGGTGACCTGCGCGCCGCCTGTGAAGCCAAAGGCACGATTCTGGCGCCCCTGGACATGATGATTGCCGCTCATGCCGT
CGCGACCGCGGCAACCCTCGTCACGCGTGACAAGGCTTTCGCTCGCATTTCTGAGCCTTTAAAGGTCGATGACTGGACGG
GCGGAAGAAGCTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10066.26 Da        Isoelectric Point: 5.1847

>AT46770 WP_039620971.1 NZ_CP007641:c3048298-3048035 [Rhizobium etli bv. phaseoli str. IE4803]
MATKTAKIFTTGRSQAVRLPAEFRFEESEVFVRRDPKTGDVILSRKPDSWDGLFELHRKDPILDDFLGPADRSQPSQDRD
PFEGWKE

Download         Length: 264 bp

>AT46770 NZ_CP007641:c3048298-3048035 [Rhizobium etli bv. phaseoli str. IE4803]
ATGGCAACGAAAACGGCTAAGATTTTTACGACCGGCCGCAGCCAGGCGGTGAGGCTCCCTGCGGAGTTTCGCTTTGAAGA
GAGCGAAGTGTTCGTTCGTCGTGATCCGAAGACCGGTGATGTCATATTATCGCGCAAGCCGGATTCATGGGATGGCCTTT
TCGAACTCCATCGGAAGGATCCGATTCTGGACGATTTCCTTGGACCGGCCGATCGTAGCCAGCCTTCGCAAGATCGGGAT
CCGTTCGAAGGTTGGAAGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4L6N3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4IRJ9

References