Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/CC2985(antitoxin)
Location 213321..213865 Replicon chromosome
Accession NZ_CP007641
Organism Rhizobium etli bv. phaseoli str. IE4803

Toxin (Protein)


Gene name parE Uniprot ID A0A7U4ILB9
Locus tag IE4803_RS00995 Protein ID WP_039617277.1
Coordinates 213575..213865 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A060I1L4
Locus tag IE4803_RS00990 Protein ID WP_038686168.1
Coordinates 213321..213572 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IE4803_RS00965 209339..210298 + 960 WP_039617273.1 glyoxylate/hydroxypyruvate reductase A -
IE4803_RS00970 210500..210880 + 381 WP_009982537.1 hypothetical protein -
IE4803_RS00975 211047..212351 + 1305 WP_004673542.1 nicotinate phosphoribosyltransferase -
IE4803_RS00980 212348..212572 - 225 WP_010057833.1 hypothetical protein -
IE4803_RS00985 212899..213108 - 210 WP_009994618.1 KTSC domain-containing protein -
IE4803_RS00990 213321..213572 + 252 WP_038686168.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
IE4803_RS00995 213575..213865 + 291 WP_039617277.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IE4803_RS01005 214215..214532 + 318 WP_038686170.1 hypothetical protein -
IE4803_RS34655 214493..214843 - 351 WP_194252161.1 hypothetical protein -
IE4803_RS01010 214842..215834 + 993 WP_039617279.1 BMP family ABC transporter substrate-binding protein -
IE4803_RS01015 215923..217434 + 1512 WP_039617281.1 ABC transporter ATP-binding protein -
IE4803_RS01020 217442..218545 + 1104 WP_039617283.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(3-70)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10913.40 Da        Isoelectric Point: 5.8267

>T46768 WP_039617277.1 NZ_CP007641:213575-213865 [Rhizobium etli bv. phaseoli str. IE4803]
MGFRLTEEAEEDIVGIAETGIRLFGSAHARRYHDELYAIFDMIAANPCMARERHEISPPMRIHPFKAHLVVYTIAEGDNV
LIVRIGHGHEDWSSQV

Download         Length: 291 bp

>T46768 NZ_CP007641:213575-213865 [Rhizobium etli bv. phaseoli str. IE4803]
ATGGGCTTTCGCCTTACGGAAGAAGCGGAAGAGGACATTGTCGGCATAGCCGAAACGGGCATTCGCCTGTTTGGCTCAGC
GCACGCTCGGCGCTACCATGATGAACTCTACGCCATTTTTGATATGATTGCTGCCAATCCCTGTATGGCGCGCGAACGGC
ATGAAATTTCTCCTCCGATGCGCATTCATCCGTTCAAGGCCCATCTCGTCGTTTATACGATTGCGGAGGGCGATAATGTT
CTCATTGTCCGTATTGGCCACGGACACGAAGATTGGTCCAGTCAGGTTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9352.44 Da        Isoelectric Point: 8.5309

>AT46768 WP_038686168.1 NZ_CP007641:213321-213572 [Rhizobium etli bv. phaseoli str. IE4803]
MATMNVSLPDPMKDWVEAQTKTGRYANASDYVRDLIRKDQERNDKVAAMQRFVDEGLKSGVGSRSKDELFEAARARVESS
RGN

Download         Length: 252 bp

>AT46768 NZ_CP007641:213321-213572 [Rhizobium etli bv. phaseoli str. IE4803]
ATGGCGACCATGAACGTATCGCTGCCCGATCCCATGAAAGATTGGGTGGAAGCGCAAACCAAAACAGGCCGTTATGCCAA
TGCGAGCGATTATGTCCGCGACCTCATCAGGAAAGATCAGGAGCGAAACGACAAGGTCGCAGCTATGCAGCGCTTTGTCG
ATGAAGGCTTGAAGAGCGGCGTCGGGTCGCGGTCGAAGGACGAGCTGTTTGAGGCGGCGCGGGCGCGCGTGGAAAGCTCT
CGCGGCAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4ILB9

Antitoxin

Source ID Structure
AlphaFold DB A0A060I1L4

References