Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1495429..1495874 Replicon chromosome
Accession NZ_CP007633
Organism Thermotoga sp. RQ7

Toxin (Protein)


Gene name hicA Uniprot ID D2C4B8
Locus tag TRQ7_RS07715 Protein ID WP_008195297.1
Coordinates 1495644..1495874 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID Q9X145
Locus tag TRQ7_RS07710 Protein ID WP_004083352.1
Coordinates 1495429..1495647 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TRQ7_RS07695 1491474..1492802 - 1329 WP_011943909.1 radical SAM protein -
TRQ7_RS07705 1493770..1495332 + 1563 WP_041844364.1 hypothetical protein -
TRQ7_RS07710 1495429..1495647 + 219 WP_004083352.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
TRQ7_RS07715 1495644..1495874 + 231 WP_008195297.1 type II toxin-antitoxin system HicA family toxin Toxin
TRQ7_RS07720 1495897..1496109 + 213 WP_004079908.1 hypothetical protein -
TRQ7_RS09550 1496099..1496248 + 150 WP_081434644.1 type II toxin-antitoxin system HicA family toxin -
TRQ7_RS07725 1496319..1498061 - 1743 WP_004079909.1 ABC transporter ATP-binding protein/permease -
TRQ7_RS09555 1498124..1498893 - 770 Protein_1502 ABC transporter permease -
TRQ7_RS07735 1498897..1499331 - 435 WP_004079914.1 ABC transporter permease -
TRQ7_RS07740 1499549..1500355 - 807 WP_004079915.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-64)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-57)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8881.54 Da        Isoelectric Point: 11.0394

>T46746 WP_008195297.1 NZ_CP007633:1495644-1495874 [Thermotoga sp. RQ7]
MSYLPIVDPKTMEKVLLKLGFQRVRQKGSHVFYRHSNGRYTTIPFHARALPKSLIRKIIREAGISVEEFKKVLENL

Download         Length: 231 bp

>T46746 NZ_CP007633:1495644-1495874 [Thermotoga sp. RQ7]
TTGAGTTATCTTCCAATAGTTGATCCAAAAACTATGGAAAAGGTTTTACTGAAACTTGGATTTCAACGTGTTCGCCAAAA
AGGAAGTCATGTGTTCTACAGGCACAGCAATGGCAGATATACGACCATCCCATTTCATGCAAGAGCCTTGCCCAAATCAC
TTATAAGAAAAATCATCCGTGAAGCGGGTATATCAGTGGAGGAATTCAAGAAAGTACTTGAGAATCTGTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8183.29 Da        Isoelectric Point: 4.0887

>AT46746 WP_004083352.1 NZ_CP007633:1495429-1495647 [Thermotoga sp. RQ7]
VRKIFTAIIEYDPETKQYVGMVPDVPGVHTVGSSLEEVRRNLKEVLELVLEEAGDEINHQEFVALEMIEVET

Download         Length: 219 bp

>AT46746 NZ_CP007633:1495429-1495647 [Thermotoga sp. RQ7]
GTGCGCAAAATTTTCACAGCTATCATTGAATACGATCCTGAAACAAAGCAATATGTTGGAATGGTTCCGGACGTTCCGGG
TGTGCATACTGTAGGTAGTTCCTTAGAAGAAGTGAGAAGGAATTTAAAAGAGGTGCTTGAACTCGTATTGGAGGAAGCAG
GAGATGAAATAAATCACCAGGAATTCGTGGCTCTTGAGATGATAGAGGTGGAAACTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B5L026

Antitoxin

Source ID Structure
AlphaFold DB A0A0A6N0B1

References