Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 240298..240910 Replicon chromosome
Accession NZ_CP007631
Organism Streptococcus agalactiae strain NGBS061

Toxin (Protein)


Gene name parE Uniprot ID Q8E1X3
Locus tag EN71_RS01405 Protein ID WP_000384858.1
Coordinates 240298..240633 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q8E1X2
Locus tag EN71_RS01410 Protein ID WP_000255538.1
Coordinates 240623..240910 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EN71_RS01375 235495..236124 + 630 WP_000591152.1 hypothetical protein -
EN71_RS01385 236437..237312 + 876 WP_000421239.1 hypothetical protein -
EN71_RS01390 237348..237782 + 435 WP_001220480.1 hypothetical protein -
EN71_RS01395 238099..239355 + 1257 WP_038405992.1 plasmid recombination protein -
EN71_RS01400 239523..239993 + 471 WP_000130119.1 hypothetical protein -
EN71_RS01405 240298..240633 - 336 WP_000384858.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EN71_RS01410 240623..240910 - 288 WP_000255538.1 hypothetical protein Antitoxin
EN71_RS01415 241417..241707 + 291 WP_000078283.1 WXG100 family type VII secretion target -
EN71_RS01420 241809..242177 + 369 WP_001882138.1 hypothetical protein -
EN71_RS12005 242215..242774 + 560 Protein_229 hypothetical protein -
EN71_RS01430 242747..243427 + 681 WP_001865565.1 hypothetical protein -
EN71_RS01435 243412..243798 + 387 WP_000259069.1 hypothetical protein -
EN71_RS01440 243832..244113 + 282 WP_000052406.1 hypothetical protein -
EN71_RS01455 244956..245816 + 861 WP_000477654.1 Rgg/GadR/MutR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 232035..241174 9139


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13264.04 Da        Isoelectric Point: 5.2388

>T46743 WP_000384858.1 NZ_CP007631:c240633-240298 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISKYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

>T46743 NZ_CP007631:c240633-240298 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGTTAAAGGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCGACATCAGGTCAGCACAAAATGGAGCAAATCATTAGTGACATAGAAAAACTCGAGGTTTTCCCTGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTAAGTACCACAGCACTAGAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGAGGAAGAGAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10921.47 Da        Isoelectric Point: 4.7271

>AT46743 WP_000255538.1 NZ_CP007631:c240910-240623 [Streptococcus agalactiae]
MVTAEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRSELGL

Download         Length: 288 bp

>AT46743 NZ_CP007631:c240910-240623 [Streptococcus agalactiae]
ATGGTTACAGCAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAGAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTTCAAAATGTCGTTGTCACAAATGAGGTTGACTTATTGA
CGGAAGAGGAGCTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAAGATGTTCGTCAA
GGGAAATTTTATACCTCTGAAGAAGTGAGGTCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1EF10

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1EFF9

References