Detailed information of TA system TA046741

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /SpoIISA(toxin)
• Location: 4951181..4952172
• Replicon: chromosome
• Accession: NZ_CP007626
• Organism: Bacillus pseudomycoides strain 219298

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: C3BKJ5
• Locus tag: MA06_RS26915
• Protein ID: WP_006094848.1
• Coordinates: 4951181..4951921 (+)
• Length: 247 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MA06_RS26920
• Protein ID: WP_018780469.1
• Coordinates: 4952044..4952172 (+)
• Length: 43 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MA06_RS26890	4946740..4947375	+	636	WP_006094853.1	TetR/AcrR family transcriptional regulator	-
MA06_RS26895	4947443..4948699	+	1257	WP_018780466.1	MFS transporter	-
MA06_RS26900	4949017..4949427	+	411	WP_018780467.1	VOC family protein	-
MA06_RS26905	4949613..4950089	+	477	WP_006094850.1	MarR family winged helix-turn-helix transcriptional regulator	-
MA06_RS26910	4950249..4950983	+	735	WP_040119579.1	2,3-diphosphoglycerate-dependent phosphoglycerate mutase	-
MA06_RS26915	4951181..4951921	+	741	WP_006094848.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
MA06_RS26920	4952044..4952172	+	129	WP_018780469.1	hypothetical protein	Antitoxin
MA06_RS26925	4952252..4952428	+	177	WP_003197743.1	hypothetical protein	-
MA06_RS26930	4952443..4952784	-	342	WP_051977368.1	GNAT family N-acetyltransferase	-
MA06_RS26935	4953126..4954592	+	1467	WP_018780471.1	aminoacyl-histidine dipeptidase	-
MA06_RS26940	4954896..4955747	+	852	WP_018780472.1	metallophosphoesterase	-
MA06_RS26945	4956053..4956304	+	252	WP_018780473.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (11-244)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 247 a.a.
• Molecular weight: 28424.14 Da
• Isoelectric Point: 6.7286

>T46741 WP_006094848.1 NZ_CP007626:4951181-4951921 [Bacillus pseudomycoides]
MTVSNIRVGLFLLVLVFLFLIFFYWKNEELYEEKKQLIRKTWYGVFITSVTMYFMMKGIDLTLWKNILMFVAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAAFGTMEWQTETEYAQSLNVFLDTYAEKIGAK
IVVFVTEGELNTNFRGIRSQFSITVPVEHIEQLNEQKAVQVENVGIIPAKIVRDVCIVIDGQKNNLQDRDFENVYNLTIH
HSYFSK

Nucleotide

• Length: 741 bp

>T46741 NZ_CP007626:4951181-4951921 [Bacillus pseudomycoides]
TTGACGGTCTCTAACATTCGAGTTGGTTTGTTTCTTCTCGTATTAGTCTTTTTATTTCTTATTTTCTTTTATTGGAAAAA
TGAAGAATTGTACGAAGAAAAAAAGCAACTTATTCGAAAAACATGGTATGGTGTGTTTATTACATCAGTCACAATGTATT
TCATGATGAAAGGAATTGATTTAACCCTCTGGAAAAATATTTTAATGTTCGTTGCAATGGTGATTTTTGTTGATATTGCA
TTTATTTTAACTCCAAACATTTCTGAAATATGGGGTGCAAAATTTAGTGATATCGGAAAGACCGTTCAATCTATTAAACG
ATCATTAATTGCTTCGAAAGCACGAGGTGAGATCTACACAACAATTATTCAAAATGTAAACCCAGCAGCATTTGGTACGA
TGGAGTGGCAAACTGAAACAGAATATGCACAAAGTTTAAATGTATTTCTTGATACGTATGCAGAAAAAATTGGGGCGAAG
ATTGTCGTATTTGTGACAGAAGGTGAATTAAATACGAATTTTCGTGGTATCCGTTCTCAATTTAGTATTACAGTTCCTGT
GGAACATATAGAACAATTAAATGAACAGAAAGCAGTGCAAGTTGAAAATGTTGGTATCATACCAGCCAAAATAGTAAGAG
ATGTTTGTATTGTTATTGATGGTCAAAAGAATAACCTTCAAGACCGGGATTTTGAAAATGTATATAACTTAACAATTCAT
CATAGTTATTTTAGTAAGTAA

Antitoxin

Protein

• Length: 43 a.a.
• Molecular weight: 4928.37 Da
• Isoelectric Point: 4.0236

>AT46741 WP_018780469.1 NZ_CP007626:4952044-4952172 [Bacillus pseudomycoides]
VEKEYGSEFFKEEAEDTTDFSLIKGDTMQQVENLEEELKRKG

Nucleotide

• Length: 129 bp

>AT46741 NZ_CP007626:4952044-4952172 [Bacillus pseudomycoides]
GTGGAAAAAGAATATGGTAGTGAATTTTTCAAAGAAGAAGCTGAAGATACAACAGATTTCTCTTTAATAAAAGGAGATAC
AATGCAGCAAGTAGAAAATTTAGAAGAAGAATTAAAAAGAAAAGGATAA

Structures

Toxin

• AlphaFold DB: C3BKJ5