Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 1704816..1705791 Replicon chromosome
Accession NZ_CP007618
Organism Bacillus anthracis strain 2000031021

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag DJ48_RS09445 Protein ID WP_002036394.1
Coordinates 1705054..1705791 (-) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag DJ48_RS09440 Protein ID WP_000588712.1
Coordinates 1704816..1704941 (-) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DJ48_RS09410 1700570..1701040 + 471 WP_000670597.1 DUF5065 family protein -
DJ48_RS09415 1701604..1703073 - 1470 WP_000287522.1 beta-Ala-His dipeptidase -
DJ48_RS30485 1703217..1703393 - 177 WP_000808045.1 hypothetical protein -
DJ48_RS09425 1703732..1703968 + 237 WP_001021688.1 hypothetical protein -
DJ48_RS09430 1704245..1704526 + 282 WP_001041555.1 hypothetical protein -
DJ48_RS30490 1704563..1704739 - 177 WP_000852615.1 hypothetical protein -
DJ48_RS09440 1704816..1704941 - 126 WP_000588712.1 hypothetical protein Antitoxin
DJ48_RS09445 1705054..1705791 - 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
DJ48_RS09450 1705980..1706717 - 738 WP_000594138.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
DJ48_RS09455 1706885..1707367 - 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
DJ48_RS09460 1707474..1709159 + 1686 WP_014654562.1 alpha-keto acid decarboxylase family protein -
DJ48_RS09465 1709281..1710063 - 783 WP_000381787.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T46735 WP_002036394.1 NZ_CP007618:c1705791-1705054 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T46735 NZ_CP007618:c1705791-1705054 [Bacillus anthracis]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTTCTTGTTTTCTTTTACTGGAGAAATGA
AGAATTGTATGAGGAGAAGAAGCAACGAATTAGAAAGACTTGGTATGGGTTGTTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACGGTTCAATCGATAAAACGGTC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATCATTCAAAATGTCAATCCAGCAGTGTTCGGTACGATGG
AATGGCATACGGAGGAAGAATATACAAAAAGCTTAAACGCATTTTTAGATTCGTATGGGGAAAAGATTGGAGCAAAAATT
GTTGTATTTGAAGCGGCAAAGGAATTAAATACAAACTTTCGTGGTATCCGTTCTCAATTTAGTACGATTATTCCGTTAGA
GTACATTGAGCAATTGAATGAGCAGAGAGCAGTACAAGTAGAAAATGTCGGAATTATACCAGCAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT46735 WP_000588712.1 NZ_CP007618:c1704941-1704816 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT46735 NZ_CP007618:c1704941-1704816 [Bacillus anthracis]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATACAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References