Detailed information of TA system TA046731

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 774737..775361
• Replicon: chromosome
• Accession: NZ_CP007605
• Organism: Helicobacter pylori strain BM012B

Toxin (Protein)

• Gene name: relE
• Uniprot ID: V5NM94
• Locus tag: EG66_RS03915
• Protein ID: WP_023592055.1
• Coordinates: 775095..775361 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V5NMW4
• Locus tag: EG66_RS03910
• Protein ID: WP_023592054.1
• Coordinates: 774737..775114 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EG66_RS03880	770005..770241	+	237	WP_000335461.1	HypC/HybG/HupF family hydrogenase formation chaperone	-
EG66_RS03885	770259..771371	+	1113	WP_023592052.1	hydrogenase formation protein HypD	-
EG66_RS03890	771322..771852	-	531	WP_038419879.1	hypothetical protein	-
EG66_RS03905	772296..774527	+	2232	WP_023591952.1	Hop family adhesin BabA	-
EG66_RS03910	774737..775114	+	378	WP_023592054.1	hypothetical protein	Antitoxin
EG66_RS03915	775095..775361	+	267	WP_023592055.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
EG66_RS03920	775467..775991	-	525	WP_001135637.1	acyl-CoA thioesterase	-
EG66_RS03925	776131..776985	+	855	WP_023592056.1	SDR family oxidoreductase	-
EG66_RS03930	776978..777958	+	981	WP_000921458.1	iron ABC transporter permease	-
EG66_RS03935	777958..778725	+	768	WP_023592057.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10332.17 Da
• Isoelectric Point: 8.0602

>T46731 WP_023592055.1 NZ_CP007605:775095-775361 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNEVILTLRKKEPLDPQFKDHALKGKWKPFRECHIKADILLVYLVENDELILLR
LGSHSELF

Nucleotide

• Length: 267 bp

>T46731 NZ_CP007605:775095-775361 [Helicobacter pylori]
GTGTTAAAACTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATGAAGTCATTCTAACCTTAAGAAAGAAAGAACCGCTAGATCCCCAATTTAAAGATCATGCTTTGAAAGGAAAGTGGA
AACCTTTTAGGGAATGCCATATTAAAGCTGATATTTTGCTTGTGTATTTAGTGGAAAATGATGAGCTGATTTTGTTAAGG
TTAGGCAGTCATAGCGAGTTGTTTTGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14715.70 Da
• Isoelectric Point: 8.9992

>AT46731 WP_023592054.1 NZ_CP007605:774737-775114 [Helicobacter pylori]
MPNSSTKKDYTKYSEKQLVNLIHQLERKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCF
GHETPNIQTQQAMRDALNKETDLIVEDFSSYSDERKKALGVKTQP

Nucleotide

• Length: 378 bp

>AT46731 NZ_CP007605:774737-775114 [Helicobacter pylori]
ATGCCTAATTCTTCCACCAAAAAAGACTACACAAAATACAGCGAAAAACAGCTTGTTAACTTAATCCATCAATTAGAGCG
AAAAATTAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTT
GGGCATGAAACCCCAAACATTCAAACGCAACAAGCCATGAGAGACGCGCTCAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAGTTACAGCGATGAAAGAAAAAAGGCGTTAGGTGTTAAAACTCAACCTTAA

Structures

Toxin

• AlphaFold DB: V5NM94

Antitoxin

• AlphaFold DB: V5NMW4