Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 860912..861536 Replicon chromosome
Accession NZ_CP007604
Organism Helicobacter pylori strain BM013A

Toxin (Protein)


Gene name relE Uniprot ID A0A024C936
Locus tag EG63_RS04120 Protein ID WP_038417767.1
Coordinates 860912..861178 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A024C118
Locus tag EG63_RS04125 Protein ID WP_038417768.1
Coordinates 861165..861536 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EG63_RS04100 857548..858315 - 768 WP_038417764.1 ABC transporter ATP-binding protein -
EG63_RS04105 858315..859295 - 981 WP_000921461.1 iron ABC transporter permease -
EG63_RS04110 859288..860142 - 855 WP_038417765.1 SDR family oxidoreductase -
EG63_RS04115 860282..860806 + 525 WP_001135628.1 acyl-CoA thioesterase -
EG63_RS04120 860912..861178 - 267 WP_038417767.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
EG63_RS04125 861165..861536 - 372 WP_038417768.1 hypothetical protein Antitoxin
EG63_RS04130 862104..863987 - 1884 Protein_790 outer membrane beta-barrel protein -
EG63_RS04145 864381..864818 + 438 WP_187288308.1 hypothetical protein -
EG63_RS04150 864769..865881 - 1113 WP_038417769.1 hydrogenase formation protein HypD -
EG63_RS04155 865899..866135 - 237 WP_000335439.1 HypC/HybG/HupF family hydrogenase formation chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10467.58 Da        Isoelectric Point: 10.4058

>T46729 WP_038417767.1 NZ_CP007604:c861178-860912 [Helicobacter pylori]
MLKIRHHIFFKKDFKKLVKNGFDDSVLKEVILTLRKKEPLPTPFKDHALKGKWKPFRECHIKADILLVYLVKDDELILLR
LGSHSELF

Download         Length: 267 bp

>T46729 NZ_CP007604:c861178-860912 [Helicobacter pylori]
ATGCTGAAAATTAGGCATCATATCTTTTTCAAAAAAGACTTTAAAAAACTTGTTAAAAATGGGTTTGATGATAGCGTTTT
GAAAGAAGTCATTCTAACCTTAAGAAAGAAAGAACCGCTACCCACACCATTTAAAGATCATGCCCTAAAAGGCAAGTGGA
AACCTTTTAGGGAATGCCACATCAAAGCCGACATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTTATTTTGTTAAGA
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 14630.57 Da        Isoelectric Point: 6.4798

>AT46729 WP_038417768.1 NZ_CP007604:c861536-861165 [Helicobacter pylori]
MPNTTAKKDYTKYSEKQLFNLIHQLERKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCF
GHEIPNIQTQQAMRDALKDENLETIEDFSAWANEVKKEMNAEN

Download         Length: 372 bp

>AT46729 NZ_CP007604:c861536-861165 [Helicobacter pylori]
ATGCCTAACACCACCGCCAAAAAAGACTACACAAAATACAGCGAAAAACAGCTTTTTAATTTAATCCATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTT
GGGCATGAGATCCCAAACATTCAAACGCAACAAGCCATGAGAGATGCATTAAAAGACGAAAACTTAGAAACTATTGAAGA
CTTTTCTGCATGGGCAAATGAAGTGAAAAAGGAAATGAATGCTGAAAATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A024C936

Antitoxin

Source ID Structure
AlphaFold DB A0A024C118

References