Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 957596..958220 Replicon chromosome
Accession NZ_CP007603
Organism Helicobacter pylori J166

Toxin (Protein)


Gene name relE Uniprot ID J0KJR7
Locus tag EG65_RS04520 Protein ID WP_000912772.1
Coordinates 957596..957862 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J0F771
Locus tag EG65_RS04525 Protein ID WP_001134056.1
Coordinates 957849..958220 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EG65_RS04500 954229..954996 - 768 WP_000242349.1 ABC transporter ATP-binding protein -
EG65_RS04505 954996..955976 - 981 WP_000921461.1 iron ABC transporter permease -
EG65_RS04510 955969..956823 - 855 WP_026938774.1 SDR family oxidoreductase -
EG65_RS04515 956963..957487 + 525 WP_001135623.1 acyl-CoA thioesterase -
EG65_RS04520 957596..957862 - 267 WP_000912772.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
EG65_RS04525 957849..958220 - 372 WP_001134056.1 hypothetical protein Antitoxin
EG65_RS04530 959029..961257 - 2229 WP_027327857.1 Hop family adhesin BabA -
EG65_RS08060 962300..962566 - 267 WP_080015166.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10448.44 Da        Isoelectric Point: 9.9214

>T46728 WP_000912772.1 NZ_CP007603:c957862-957596 [Helicobacter pylori J166]
MLKIKHHILFKKDFKKLVKNGFDDSVLNEVILTLRKKEPLDPQFQDHALKGKWKPFRECHIKPDVLLVYLVKDDELILLR
LGSHSELF

Download         Length: 267 bp

>T46728 NZ_CP007603:c957862-957596 [Helicobacter pylori J166]
ATGCTGAAAATTAAGCATCATATCCTTTTCAAAAAAGACTTTAAAAAACTTGTTAAAAATGGGTTTGATGATAGCGTTTT
GAATGAAGTCATTCTAACCTTAAGAAAAAAAGAACCGCTAGATCCCCAATTTCAAGATCATGCCTTAAAGGGAAAGTGGA
AGCCTTTTAGGGAATGCCACATTAAGCCTGATGTTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTGATTTTGTTAAGG
TTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 14438.20 Da        Isoelectric Point: 4.8704

>AT46728 WP_001134056.1 NZ_CP007603:c958220-957849 [Helicobacter pylori J166]
MPNTTAEKDYTQYSEKQLFNLIHQLEQKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GHEIPNIQTQQAMRDALSGENLETIEDFSAWANEVKKEVNAEN

Download         Length: 372 bp

>AT46728 NZ_CP007603:c958220-957849 [Helicobacter pylori J166]
ATGCCTAACACCACCGCAGAAAAAGACTACACCCAATACAGCGAAAAACAGCTTTTTAATTTAATCCATCAATTAGAGCA
AAAAATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCGTTAAATGAACTCTTGCAAAAAATCAGCCAGGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCATGAGATCCCAAACATTCAAACGCAACAAGCCATGAGAGATGCGTTAAGTGGCGAAAACTTAGAAACTATTGAAGA
CTTTTCTGCATGGGCAAATGAAGTGAAAAAGGAAGTGAATGCTGAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A024BWN4

Antitoxin

Source ID Structure
AlphaFold DB A0A024BX95

References