Detailed information of TA system TA046725

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 1308250..1308764
• Replicon: chromosome
• Accession: NZ_CP007601
• Organism: Staphylococcus capitis subsp. capitis strain AYP1020

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: ayp1020_RS06240
• Protein ID: WP_047796511.1
• Coordinates: 1308250..1308456 (-)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: A0A1J4E888
• Locus tag: ayp1020_RS06245
• Protein ID: WP_002435858.1
• Coordinates: 1308471..1308764 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ayp1020_RS06225	1303863..1305218	-	1356	WP_047796509.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-
ayp1020_RS06230	1305234..1306304	-	1071	WP_002435813.1	D-alanine--D-alanine ligase	-
ayp1020_RS06235	1306709..1307920	+	1212	WP_047796510.1	rod shape-determining protein RodA	-
ayp1020_RS12270	1307976..1308113	-	138	WP_002435861.1	hypothetical protein	-
ayp1020_RS06240	1308250..1308456	-	207	WP_047796511.1	hypothetical protein	Toxin
ayp1020_RS06245	1308471..1308764	-	294	WP_002435858.1	copper-sensing transcriptional repressor CsoR	Antitoxin
ayp1020_RS06250	1308950..1310434	+	1485	WP_047796512.1	cardiolipin synthase	-
ayp1020_RS06255	1310491..1311153	+	663	WP_047796513.1	HD domain-containing protein	-
ayp1020_RS06260	1311212..1312084	-	873	WP_002435877.1	membrane protein insertase YidC	-
ayp1020_RS06265	1312173..1312811	-	639	WP_047796514.1	thiamine phosphate synthase	-
ayp1020_RS06270	1312818..1313606	-	789	WP_002435520.1	hydroxyethylthiazole kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Metal-sensitive transcriptional repressor (14-92)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7834.89 Da
• Isoelectric Point: 4.2987

>T46725 WP_047796511.1 NZ_CP007601:c1308456-1308250 [Staphylococcus capitis subsp. capitis]
MENGIVYIANIETIEEENQLKTRLENMIGVEKVNIDSKVGEIKVLFETPANLNSIEKEVYDSGFRVRY

Nucleotide

• Length: 207 bp

>T46725 NZ_CP007601:c1308456-1308250 [Staphylococcus capitis subsp. capitis]
ATGGAAAATGGAATTGTTTATATTGCTAATATTGAGACTATAGAGGAAGAAAACCAATTAAAGACACGTTTAGAAAATAT
GATTGGTGTCGAAAAAGTAAATATTGATAGTAAAGTAGGAGAAATAAAGGTATTATTTGAAACGCCTGCGAATTTAAATA
GTATTGAAAAAGAAGTATATGATTCTGGCTTTCGCGTGCGTTATTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11065.56 Da
• Isoelectric Point: 6.4776

>AT46725 WP_002435858.1 NZ_CP007601:c1308764-1308471 [Staphylococcus capitis subsp. capitis]
VTENETAHHSEQTKANLKSRLNRIEGQVRAINRMIEDDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMNKVNNGAQ
EEAMEELLVTFQKLIKD

Nucleotide

• Length: 294 bp

>AT46725 NZ_CP007601:c1308764-1308471 [Staphylococcus capitis subsp. capitis]
GTGACTGAAAATGAAACTGCACATCACTCAGAGCAAACGAAAGCAAATCTAAAGTCACGATTAAATCGTATCGAAGGTCA
AGTACGTGCAATTAATCGAATGATTGAAGACGATGTGTATTGCGATGATGTTTTAACTCAAATAAGAGCGACACGCTCTG
CTTTAAACAGTGTGGCTACTAAATTGTTAGATCATCATATGAAAAGTTGTATTATGAATAAAGTGAATAATGGTGCGCAA
GAAGAAGCGATGGAAGAACTATTGGTTACTTTTCAAAAATTAATTAAAGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A1J4E888