46724

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1297197..1297720 Replicon chromosome
Accession NZ_CP007601
Organism Staphylococcus capitis subsp. capitis strain AYP1020

Toxin (Protein)


Gene name mazF Uniprot ID A0A1J4E8Y2
Locus tag ayp1020_RS06185 Protein ID WP_002435799.1
Coordinates 1297197..1297553 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1J4E747
Locus tag ayp1020_RS06190 Protein ID WP_002435513.1
Coordinates 1297550..1297720 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ayp1020_RS06165 1294163..1294933 - 771 WP_002435824.1 RNA polymerase sigma factor SigB -
ayp1020_RS06170 1294908..1295387 - 480 WP_002435518.1 anti-sigma B factor RsbW -
ayp1020_RS06175 1295389..1295715 - 327 WP_002435753.1 anti-sigma factor antagonist -
ayp1020_RS06180 1295817..1296818 - 1002 WP_002453685.1 PP2C family protein-serine/threonine phosphatase -
ayp1020_RS06185 1297197..1297553 - 357 WP_002435799.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ayp1020_RS06190 1297550..1297720 - 171 WP_002435513.1 hypothetical protein Antitoxin
ayp1020_RS06195 1297809..1298957 - 1149 WP_047796504.1 alanine racemase -
ayp1020_RS06200 1299024..1299380 - 357 WP_047796505.1 holo-ACP synthase -
ayp1020_RS06205 1299429..1299929 - 501 WP_047796506.1 PH domain-containing protein -
ayp1020_RS06210 1299922..1301421 - 1500 WP_047796507.1 PH domain-containing protein -
ayp1020_RS06215 1301414..1301893 - 480 WP_047796508.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13327.44 Da        Isoelectric Point: 9.8770

>T46724 WP_002435799.1 NZ_CP007601:c1297553-1297197 [Staphylococcus capitis subsp. capitis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSESKMKEVDNALDISLGLHNFDHQ

Download         Length: 357 bp

>T46724 NZ_CP007601:c1297553-1297197 [Staphylococcus capitis subsp. capitis]
ATGATTAGAAGAGGCGATGTTTACTTAGCTGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTTGT
AATTATACAAAATGATACTGGTAATAAATATAGTCCAACTGTCATAGTTGCTGCTATTACAGGTAGGATTAATAAAGCGA
AGATACCAACCCATGTAGAAATTGAAAAGAAAAAATATAAGTTAGATAAAGACTCTGTTATCTTACTTGAACAAATTAGA
ACACTAGATAAAAAACGTTTAAAAGAGAAGTTGACCTATTTGTCTGAAAGTAAGATGAAGGAAGTTGACAACGCCCTAGA
TATCAGTCTAGGATTACATAATTTTGACCATCAATGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6263.87 Da        Isoelectric Point: 4.0121

>AT46724 WP_002435513.1 NZ_CP007601:c1297720-1297550 [Staphylococcus capitis subsp. capitis]
MLSFNQSRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNSKNE

Download         Length: 171 bp

>AT46724 NZ_CP007601:c1297720-1297550 [Staphylococcus capitis subsp. capitis]
ATGTTATCTTTTAATCAATCTAGGAGTCACAGTCTTGAACAATCATTAAAAGAAGGCTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACGGAAGCTTTTCCCATCGAATGTGAAGCTTGCGATTGTAATGAAACATATCTTACTTCTAACTCTA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J4E8Y2

Antitoxin

Source ID Structure
AlphaFold DB A0A1J4E747

References