Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1155217..1156023 Replicon chromosome
Accession NZ_CP007601
Organism Staphylococcus capitis subsp. capitis strain AYP1020

Toxin (Protein)


Gene name tsbT Uniprot ID A0A1J4EAU5
Locus tag ayp1020_RS05395 Protein ID WP_002434789.1
Coordinates 1155217..1155396 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A1J4ECT8
Locus tag ayp1020_RS05400 Protein ID WP_002453580.1
Coordinates 1155424..1156023 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ayp1020_RS05370 1150256..1150879 - 624 WP_047796436.1 response regulator transcription factor -
ayp1020_RS05375 1150899..1152011 - 1113 WP_047796437.1 GAF domain-containing sensor histidine kinase -
ayp1020_RS05380 1152187..1153017 + 831 WP_047796438.1 RluA family pseudouridine synthase -
ayp1020_RS05385 1153115..1154500 - 1386 WP_047796439.1 class II fumarate hydratase -
ayp1020_RS05390 1154654..1155052 - 399 WP_023350046.1 hypothetical protein -
ayp1020_RS05395 1155217..1155396 - 180 WP_002434789.1 hypothetical protein Toxin
ayp1020_RS05400 1155424..1156023 - 600 WP_002453580.1 glucosamine-6-phosphate isomerase Antitoxin
ayp1020_RS05405 1156204..1156674 - 471 WP_047796440.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
ayp1020_RS05410 1156677..1157840 - 1164 WP_103157074.1 tRNA epoxyqueuosine(34) reductase QueG -
ayp1020_RS05415 1157963..1158685 - 723 WP_047796441.1 amino acid ABC transporter ATP-binding protein -
ayp1020_RS05420 1158678..1160135 - 1458 WP_023350042.1 ABC transporter substrate-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 7005.38 Da        Isoelectric Point: 3.9242

>T46723 WP_002434789.1 NZ_CP007601:c1155396-1155217 [Staphylococcus capitis subsp. capitis]
MNKEHESKLNYHEEENAMVTDLDDLKELGKEMEQISEENDEDKLNQSHDEDVRSDLNNE

Download         Length: 180 bp

>T46723 NZ_CP007601:c1155396-1155217 [Staphylococcus capitis subsp. capitis]
ATGAATAAAGAACATGAATCTAAATTGAATTATCATGAAGAAGAAAATGCTATGGTCACAGATTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAAATTTCAGAAGAAAATGATGAAGATAAATTAAACCAATCTCATGATGAAGATGTTCGTT
CTGACCTTAATAATGAATAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22720.63 Da        Isoelectric Point: 4.7928

>AT46723 WP_002453580.1 NZ_CP007601:c1156023-1155424 [Staphylococcus capitis subsp. capitis]
MAMNFKVFENSERVAEYAADIIRKQFNNNPTTIAGFHLEKDHAPVLDELKKNVDTHAVDFSQINILDYDDNRSYYEALGV
PESQVYSISYEQDAIDFISDKMKTKENKGKLILQVLSIDESGKLDVSVRQGLMEAREIFLVVTGSNKREVIEKLYRENGK
SSYEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARYV

Download         Length: 600 bp

>AT46723 NZ_CP007601:c1156023-1155424 [Staphylococcus capitis subsp. capitis]
ATGGCAATGAACTTTAAAGTATTTGAAAATAGTGAAAGAGTAGCAGAATATGCTGCAGATATTATTCGTAAACAATTTAA
TAATAATCCAACTACAATTGCAGGTTTTCACTTAGAAAAAGATCACGCACCTGTATTAGATGAACTTAAGAAAAATGTAG
ATACGCATGCTGTAGATTTCAGCCAAATCAATATTTTAGATTATGATGATAATAGATCTTATTATGAAGCATTAGGTGTA
CCTGAAAGCCAAGTGTATTCAATTTCTTACGAACAAGATGCAATTGATTTTATTTCAGATAAAATGAAAACTAAAGAAAA
TAAAGGTAAATTAATCCTTCAAGTTCTTTCAATTGATGAAAGTGGCAAGTTAGATGTAAGTGTACGTCAAGGCCTTATGG
AAGCTAGAGAAATCTTCTTAGTTGTTACAGGTAGTAATAAACGTGAAGTTATTGAAAAACTTTATCGTGAAAACGGCAAA
TCTAGTTATGAGCCAGCAGATCTTAAAGCACACCGCATGGTAAATGTTATTTTAGATAAAGAAGCGGCTGCAGGATTACC
TGAGGATGTTAAAGAATACTTCACAGCACGTTATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J4EAU5

Antitoxin

Source ID Structure
AlphaFold DB A0A1J4ECT8

References