Detailed information of TA system TA046718

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 30545..31189
• Replicon: plasmid pCFSAN000111_01
• Accession: NZ_CP007599
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis str. 77-1427

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A7L6LII1
• Locus tag: SEEE1427_RS22825
• Protein ID: WP_000833471.1
• Coordinates: 31007..31189 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A7L6LHN8
• Locus tag: SEEE1427_RS22820
• Protein ID: WP_000466317.1
• Coordinates: 30545..30982 (-)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SEEE1427_RS22800	27956..28291	-	336	WP_000963832.1	hypothetical protein	-
SEEE1427_RS22805	28637..29044	+	408	WP_001190621.1	hypothetical protein	-
SEEE1427_RS22810	29054..29815	+	762	WP_001097938.1	conjugal transfer protein TraL	-
SEEE1427_RS22815	29812..30516	+	705	WP_001279862.1	hypothetical protein	-
SEEE1427_RS22820	30545..30982	-	438	WP_000466317.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
SEEE1427_RS22825	31007..31189	-	183	WP_000833471.1	type II toxin-antitoxin system HicA family toxin	Toxin
SEEE1427_RS22830	31622..31900	-	279	WP_000545932.1	hypothetical protein	-
SEEE1427_RS22835	31958..32287	-	330	WP_000855123.1	hypothetical protein	-
SEEE1427_RS22840	32726..32968	-	243	WP_001704452.1	transcriptional regulator	-
SEEE1427_RS22845	32958..33224	-	267	WP_000868277.1	hypothetical protein	-
SEEE1427_RS22850	33275..33499	-	225	WP_000749828.1	hypothetical protein	-
SEEE1427_RS22855	33595..33819	-	225	WP_000866038.1	hypothetical protein	-
SEEE1427_RS22860	33862..34185	-	324	WP_000432875.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..39599	39599

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-108)

Antitoxin

• Antitoxin CbeA (5-104)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 8995.79 Da
• Isoelectric Point: 5.5500

>T46718 WP_000833471.1 NZ_CP007599:c31189-31007 [Salmonella enterica subsp. enterica serovar Enteritidis str.]
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Nucleotide

• Length: 183 bp

>T46718 NZ_CP007599:c31189-31007 [Salmonella enterica subsp. enterica serovar Enteritidis str.]
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Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 21505.80 Da
• Isoelectric Point: 5.5500

>AT46718 WP_000466317.1 NZ_CP007599:c30982-30545 [Salmonella enterica subsp. enterica serovar Enteritidis str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 438 bp

>AT46718 NZ_CP007599:c30982-30545 [Salmonella enterica subsp. enterica serovar Enteritidis str.]
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Structures

Toxin

• AlphaFold DB: A0A7L6LII1

Antitoxin

• AlphaFold DB: A0A7L6LHN8