Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 4022512..4023066 Replicon chromosome
Accession NZ_CP007595
Organism Arthrobacter sp. PAMC 25486

Toxin (Protein)


Gene name relE Uniprot ID A0A0A1D1V8
Locus tag art_RS18180 Protein ID WP_038467190.1
Coordinates 4022512..4022778 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0A1D6I5
Locus tag art_RS18185 Protein ID WP_038467193.1
Coordinates 4022779..4023066 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
art_RS18170 4019666..4021342 + 1677 WP_038467184.1 acyl-CoA dehydrogenase family protein -
art_RS18175 4021435..4022334 + 900 WP_038467187.1 alpha/beta fold hydrolase -
art_RS18180 4022512..4022778 - 267 WP_038467190.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
art_RS18185 4022779..4023066 - 288 WP_038467193.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
art_RS18190 4023231..4023668 - 438 WP_038470908.1 hypothetical protein -
art_RS18195 4023689..4024540 - 852 WP_038467196.1 cytochrome c biogenesis CcdA family protein -
art_RS18200 4024543..4025232 - 690 WP_157875457.1 thioredoxin domain-containing protein -
art_RS18205 4025435..4025845 - 411 WP_038467202.1 hypothetical protein -
art_RS18210 4026430..4026633 + 204 WP_038467205.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 9980.62 Da        Isoelectric Point: 10.0105

>T46717 WP_038467190.1 NZ_CP007595:c4022778-4022512 [Arthrobacter sp. PAMC 25486]
VSYEVIVSPTASRDMQRIPPRIVPAIIEFVYSDLSRIPQRVGKPLERKLTGYYSARRGPYRVLFSIDEGQIAVMVAPVAH
RADVYPIH

Download         Length: 267 bp

>T46717 NZ_CP007595:c4022778-4022512 [Arthrobacter sp. PAMC 25486]
GTGTCCTATGAGGTGATTGTCTCCCCCACGGCCAGCCGCGACATGCAACGCATTCCCCCTAGGATCGTGCCCGCCATCAT
CGAGTTCGTCTACAGCGATCTGTCAAGAATTCCGCAAAGAGTTGGCAAGCCGTTGGAGCGGAAGCTCACCGGCTATTATT
CGGCCCGACGAGGCCCGTACAGGGTTCTATTTTCCATTGACGAGGGACAAATTGCCGTGATGGTGGCTCCCGTAGCCCAC
CGAGCCGACGTCTATCCCATTCATTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10303.64 Da        Isoelectric Point: 4.4633

>AT46717 WP_038467193.1 NZ_CP007595:c4023066-4022779 [Arthrobacter sp. PAMC 25486]
MQILPLSTVKARLSELVDSAALTRNEVVITKNGRPAAVIVGTDAWESLQETLFWLSQPDIREDVAQAKAEIAAGEGLSEE
EIRAQFGVPNRKGNS

Download         Length: 288 bp

>AT46717 NZ_CP007595:c4023066-4022779 [Arthrobacter sp. PAMC 25486]
ATGCAAATACTCCCTCTGTCCACAGTCAAAGCCAGGCTTTCCGAGCTGGTTGATTCTGCTGCGCTGACGCGCAACGAGGT
CGTCATTACCAAGAACGGCCGCCCGGCCGCTGTAATTGTCGGAACCGATGCGTGGGAGTCACTGCAGGAGACGCTATTCT
GGCTGTCCCAGCCAGACATTCGCGAAGACGTCGCTCAAGCCAAGGCTGAAATTGCTGCCGGTGAGGGACTCTCCGAGGAG
GAAATTCGCGCTCAGTTCGGTGTTCCCAACCGGAAGGGGAACTCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A1D1V8

Antitoxin

Source ID Structure
AlphaFold DB A0A0A1D6I5

References