Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-pasA/RelE-HTH
Location 2121609..2122093 Replicon chromosome
Accession NZ_CP007595
Organism Arthrobacter sp. PAMC 25486

Toxin (Protein)


Gene name relE Uniprot ID A0A0A1CZP4
Locus tag art_RS09715 Protein ID WP_038464526.1
Coordinates 2121609..2121875 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A0A1CWV9
Locus tag art_RS09720 Protein ID WP_038464529.1
Coordinates 2121872..2122093 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
art_RS09700 2116913..2118808 - 1896 WP_052136939.1 cadmium-translocating P-type ATPase -
art_RS09705 2118989..2120596 - 1608 WP_038464520.1 chaperonin GroEL -
art_RS09710 2120696..2120992 - 297 WP_038464523.1 co-chaperone GroES -
art_RS09715 2121609..2121875 - 267 WP_038464526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
art_RS09720 2121872..2122093 - 222 WP_038464529.1 ribbon-helix-helix protein, CopG family Antitoxin
art_RS09725 2122256..2123419 - 1164 WP_162182051.1 MFS transporter -
art_RS21650 2123738..2124292 - 555 WP_082000224.1 AAA family ATPase -
art_RS09730 2124643..2125533 + 891 WP_038464536.1 ABC transporter ATP-binding protein -
art_RS09735 2125530..2126339 + 810 WP_038464538.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-88)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10456.84 Da        Isoelectric Point: 9.4302

>T46716 WP_038464526.1 NZ_CP007595:c2121875-2121609 [Arthrobacter sp. PAMC 25486]
VTSRWQVETTAEFDREYKKLDRVVQQRVMVYLEEIETLEDPRQRGKGLAANHSGVWRYRVGDYRILAQITDSTFTVLAIR
VGHRRDIY

Download         Length: 267 bp

>T46716 NZ_CP007595:c2121875-2121609 [Arthrobacter sp. PAMC 25486]
GTGACGTCGCGGTGGCAGGTTGAAACCACCGCAGAGTTCGACCGCGAGTATAAGAAGCTTGACCGGGTGGTCCAGCAGCG
CGTGATGGTCTACCTCGAGGAAATCGAAACCCTTGAGGATCCTCGTCAGCGAGGCAAAGGGCTTGCCGCCAACCACTCCG
GCGTGTGGCGTTACCGCGTTGGCGACTACCGCATCCTCGCCCAGATTACCGATAGCACCTTCACCGTACTGGCCATTCGA
GTAGGCCACCGCCGCGACATTTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8256.26 Da        Isoelectric Point: 4.8228

>AT46716 WP_038464529.1 NZ_CP007595:c2122093-2121872 [Arthrobacter sp. PAMC 25486]
MTISIRLTPDEEARLDVLTQRTGRSKSFYVRTALHEYLADLEDAFAADSAIAVFEAEGRRSRPLAELKAETER

Download         Length: 222 bp

>AT46716 NZ_CP007595:c2122093-2121872 [Arthrobacter sp. PAMC 25486]
ATGACTATCTCAATTCGACTCACACCCGATGAAGAAGCCCGCCTTGATGTTCTCACGCAGCGCACCGGCCGGTCTAAGAG
CTTCTATGTCAGGACCGCGCTCCATGAGTATCTTGCAGACCTCGAAGATGCATTCGCAGCAGATTCCGCTATCGCGGTTT
TCGAAGCCGAGGGCCGTCGCAGCAGGCCGTTGGCCGAGTTGAAGGCTGAGACGGAACGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A1CZP4

Antitoxin

Source ID Structure
AlphaFold DB A0A0A1CWV9

References