Detailed information of TA system TA046714

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 610609..611108
• Replicon: chromosome
• Accession: NZ_CP007595
• Organism: Arthrobacter sp. PAMC 25486

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0A1CTJ9
• Locus tag: art_RS02955
• Protein ID: WP_038462404.1
• Coordinates: 610609..610866 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: art_RS02960
• Protein ID: WP_038462406.1
• Coordinates: 610863..611108 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
art_RS02940	606472..607497	-	1026	WP_038462398.1	TniB family NTP-binding protein	-
art_RS02945	607488..609596	-	2109	WP_038462400.1	DDE-type integrase/transposase/recombinase	-
art_RS02950	609593..610240	-	648	WP_038462402.1	TnsA-like heteromeric transposase endonuclease subunit	-
art_RS02955	610609..610866	-	258	WP_038462404.1	Txe/YoeB family addiction module toxin	Toxin
art_RS02960	610863..611108	-	246	WP_038462406.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
art_RS02965	611514..613904	-	2391	WP_038462408.1	excinuclease ABC subunit UvrA	-
art_RS02970	614073..614504	-	432	WP_052135940.1	GNAT family N-acetyltransferase	-
art_RS02975	614488..614874	-	387	WP_162182026.1	hypothetical protein	-
art_RS02980	614931..615677	-	747	WP_038462412.1	aminoglycoside phosphotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-70)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10050.60 Da
• Isoelectric Point: 8.4321

>T46714 WP_038462404.1 NZ_CP007595:c610866-610609 [Arthrobacter sp. PAMC 25486]
MRLAFTPHAWDDYTYWLGADKAMLTRINRLINDALRDPAAGIGKPEPLRYMFAGVWSRRITEEHRLVYLVEGEDLIILQA
RYHYK

Nucleotide

• Length: 258 bp

>T46714 NZ_CP007595:c610866-610609 [Arthrobacter sp. PAMC 25486]
ATGAGACTCGCATTTACACCCCATGCCTGGGATGACTACACATACTGGCTTGGTGCCGACAAGGCAATGCTCACGCGAAT
CAACCGCTTGATAAACGATGCTTTGCGGGATCCTGCGGCAGGCATTGGCAAGCCGGAACCATTGCGCTATATGTTTGCTG
GCGTCTGGTCCCGACGGATCACCGAAGAGCATCGCCTTGTGTACCTTGTTGAGGGCGAAGACCTGATCATCTTGCAGGCT
CGATACCACTACAAATAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9185.36 Da
• Isoelectric Point: 5.1023

>AT46714 WP_038462406.1 NZ_CP007595:c611108-610863 [Arthrobacter sp. PAMC 25486]
MSVTASEARKNLFPLIEQVNNDRMAIRITSRKGDAVLLSRDEYEALEETAYLLRVPANAKRLLESLQQASTGNFHEHDLV
E

Nucleotide

• Length: 246 bp

>AT46714 NZ_CP007595:c611108-610863 [Arthrobacter sp. PAMC 25486]
ATGTCCGTAACGGCCAGTGAGGCAAGAAAGAATCTCTTTCCCTTGATTGAGCAGGTGAACAACGACCGCATGGCGATTCG
GATTACCTCCCGGAAGGGCGACGCGGTCCTGCTCTCAAGGGACGAGTACGAAGCTCTCGAGGAAACGGCGTACTTGCTGC
GTGTACCCGCGAATGCCAAGCGCCTGCTGGAGAGCCTGCAGCAAGCAAGCACCGGGAACTTTCATGAGCATGACCTTGTG
GAATGA

Structures

Toxin

• AlphaFold DB: A0A0A1CTJ9