Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1844753..1845421 Replicon chromosome
Accession NZ_CP007593
Organism Streptococcus pneumoniae strain NT_110_58

Toxin (Protein)


Gene name hicA Uniprot ID A0A064C2E7
Locus tag spnnt_RS09320 Protein ID WP_016397531.1
Coordinates 1845242..1845421 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A064BWM8
Locus tag spnnt_RS09315 Protein ID WP_016397530.1
Coordinates 1844753..1845205 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
spnnt_RS09290 1840643..1841386 - 744 WP_016399292.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
spnnt_RS09295 1841388..1842341 - 954 WP_023928724.1 50S ribosomal protein L11 methyltransferase -
spnnt_RS09300 1842476..1842904 - 429 WP_016397528.1 NUDIX hydrolase -
spnnt_RS09305 1842906..1843973 - 1068 WP_016397529.1 M50 family metallopeptidase -
spnnt_RS09310 1843992..1844462 - 471 WP_000257102.1 DUF3013 family protein -
spnnt_RS09315 1844753..1845205 - 453 WP_016397530.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
spnnt_RS09320 1845242..1845421 - 180 WP_016397531.1 type II toxin-antitoxin system HicA family toxin Toxin
spnnt_RS09325 1845558..1845806 - 249 WP_000797237.1 hypothetical protein -
spnnt_RS09330 1845796..1846011 - 216 WP_078141963.1 hypothetical protein -
spnnt_RS09335 1846309..1847580 + 1272 WP_001113205.1 replication-associated recombination protein A -
spnnt_RS09345 1847982..1849238 - 1257 WP_023930333.1 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1847982..1849238 1256


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6709.96 Da        Isoelectric Point: 11.0174

>T46688 WP_016397531.1 NZ_CP007593:c1845421-1845242 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKIRGGKGSHIKMEKQGERPITIPHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T46688 NZ_CP007593:c1845421-1845242 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGATTAGAGGCGGTAAAGGTTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCCTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16689.48 Da        Isoelectric Point: 3.7220

>AT46688 WP_016397530.1 NZ_CP007593:c1845205-1844753 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQT

Download         Length: 453 bp

>AT46688 NZ_CP007593:c1845205-1844753 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTAACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAACCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A064C2E7

Antitoxin

Source ID Structure
AlphaFold DB A0A064BWM8

References