Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 1844753..1845421 | Replicon | chromosome |
Accession | NZ_CP007593 | ||
Organism | Streptococcus pneumoniae strain NT_110_58 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | A0A064C2E7 |
Locus tag | spnnt_RS09320 | Protein ID | WP_016397531.1 |
Coordinates | 1845242..1845421 (-) | Length | 60 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | A0A064BWM8 |
Locus tag | spnnt_RS09315 | Protein ID | WP_016397530.1 |
Coordinates | 1844753..1845205 (-) | Length | 151 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
spnnt_RS09290 | 1840643..1841386 | - | 744 | WP_016399292.1 | 16S rRNA (uracil(1498)-N(3))-methyltransferase | - |
spnnt_RS09295 | 1841388..1842341 | - | 954 | WP_023928724.1 | 50S ribosomal protein L11 methyltransferase | - |
spnnt_RS09300 | 1842476..1842904 | - | 429 | WP_016397528.1 | NUDIX hydrolase | - |
spnnt_RS09305 | 1842906..1843973 | - | 1068 | WP_016397529.1 | M50 family metallopeptidase | - |
spnnt_RS09310 | 1843992..1844462 | - | 471 | WP_000257102.1 | DUF3013 family protein | - |
spnnt_RS09315 | 1844753..1845205 | - | 453 | WP_016397530.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
spnnt_RS09320 | 1845242..1845421 | - | 180 | WP_016397531.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
spnnt_RS09325 | 1845558..1845806 | - | 249 | WP_000797237.1 | hypothetical protein | - |
spnnt_RS09330 | 1845796..1846011 | - | 216 | WP_078141963.1 | hypothetical protein | - |
spnnt_RS09335 | 1846309..1847580 | + | 1272 | WP_001113205.1 | replication-associated recombination protein A | - |
spnnt_RS09345 | 1847982..1849238 | - | 1257 | WP_023930333.1 | ISL3 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | flank | IS/Tn | - | - | 1847982..1849238 | 1256 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 60 a.a. Molecular weight: 6709.96 Da Isoelectric Point: 11.0174
>T46688 WP_016397531.1 NZ_CP007593:c1845421-1845242 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKIRGGKGSHIKMEKQGERPITIPHGELNKYTERGIRKQAGL
MPMTQKEMVKLLTAHGWIKIRGGKGSHIKMEKQGERPITIPHGELNKYTERGIRKQAGL
Download Length: 180 bp
>T46688 NZ_CP007593:c1845421-1845242 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGATTAGAGGCGGTAAAGGTTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCCTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGATTAGAGGCGGTAAAGGTTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCCTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA
Antitoxin
Download Length: 151 a.a. Molecular weight: 16689.48 Da Isoelectric Point: 3.7220
>AT46688 WP_016397530.1 NZ_CP007593:c1845205-1844753 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQT
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQT
Download Length: 453 bp
>AT46688 NZ_CP007593:c1845205-1844753 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTAACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAACCTAA
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTAACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAACCTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A064C2E7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A064BWM8 |