Detailed information of TA system TA046686

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): zeta-pezA/zeta-couple_hipB
• Location: 1271327..1272579
• Replicon: chromosome
• Accession: NZ_CP007593
• Organism: Streptococcus pneumoniae strain NT_110_58

Toxin (Protein)

• Gene name: zeta
• Uniprot ID: A0A822RLP0
• Locus tag: spnnt_RS06270
• Protein ID: WP_039704023.1
• Coordinates: 1271327..1272103 (-)
• Length: 259 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: spnnt_RS06275
• Protein ID: WP_025173761.1
• Coordinates: 1272103..1272579 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
spnnt_RS06255	1266630..1267526	-	897	WP_016398059.1	restriction endonuclease	-
spnnt_RS06260	1267577..1270537	-	2961	Protein_1208	DEAD/DEAH box helicase	-
spnnt_RS06265	1270534..1271343	-	810	WP_016398058.1	DUF1837 domain-containing protein	-
spnnt_RS06270	1271327..1272103	-	777	WP_039704023.1	zeta toxin family protein	Toxin
spnnt_RS06275	1272103..1272579	-	477	WP_025173761.1	helix-turn-helix domain-containing protein	Antitoxin
spnnt_RS06280	1273024..1273479	-	456	WP_016397781.1	hypothetical protein	-
spnnt_RS06290	1273805..1275493	-	1689	WP_016399224.1	glycoside hydrolase family 13 protein	-
spnnt_RS06295	1275656..1276489	-	834	WP_016399225.1	diacylglycerol kinase family lipid kinase	-
spnnt_RS06300	1276651..1277505	-	855	WP_016399226.1	ADP-ribosylglycohydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1267565..1279188	11623

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 259 a.a.
• Molecular weight: 29422.33 Da
• Isoelectric Point: 6.7030

>T46686 WP_039704023.1 NZ_CP007593:c1272103-1271327 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLGYNLLIEGTLRTIDVPKETAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFESIQIYQRDRSCVYDSKENTTSAATVLHDLLFGEWNTVEKEML
KIGQERLWDMSKSNGKDA

Nucleotide

• Length: 777 bp

>T46686 NZ_CP007593:c1272103-1271327 [Streptococcus pneumoniae]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTTTAGCAAGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTGCTTGGAGGGCAAAGTGGTGCTGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGATAGCGTTGAATACACCAAAGATTTTGCAGGAAAAATGGTAGAGTCTTTAGTAACAAAATTGAGTAG
TTTGGGATACAATCTTTTGATCGAGGGAACTTTACGAACGATTGACGTTCCAAAGGAAACAGCACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTAGCCTTGATTGCGACAAAGCCTGAGCTGTCCTATCTGAGCACTCTTATCCGATACGAAGAA
CTGTACGCTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTGGAAGAACTGGCTATCTTTGAAAGCATTCAAATTTATCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAACAGTTCTTCATGACTTACTATTTGGAGAATGGAACACGGTTGAAAAAGAGATGTTG
AAGATAGGGCAGGAACGGTTGTGGGATATGAGTAAAAGTAATGGAAAAGATGCATAG

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18279.70 Da
• Isoelectric Point: 4.4188

>AT46686 WP_025173761.1 NZ_CP007593:c1272579-1272103 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMFNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

>AT46686 NZ_CP007593:c1272579-1272103 [Streptococcus pneumoniae]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACACAACCCGAATTTGCACGAATTATAGGAATTTC
TCGAAATAGCTTGAGTCGTTATGAAAATGGAACTAGTTCAGTCTCTACGGAACTAATAGATATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGTTCAATCCTGTTGAAGATTATGAATTGACTTTGAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCATACGAATATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGTGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAGCGGATGGTAGCTTAA

Structures

Toxin

• AlphaFold DB: A0A822RLP0