46685

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1114449..1114947 Replicon chromosome
Accession NZ_CP007593
Organism Streptococcus pneumoniae strain NT_110_58

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag spnnt_RS05515 Protein ID WP_001809704.1
Coordinates 1114693..1114947 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag spnnt_RS05510 Protein ID WP_000208080.1
Coordinates 1114449..1114691 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
spnnt_RS05490 1110270..1111445 + 1176 WP_000886145.1 A/G-specific adenine glycosylase -
spnnt_RS05495 1111501..1112205 + 705 WP_000722076.1 response regulator transcription factor -
spnnt_RS05500 1112198..1113547 + 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
spnnt_RS05505 1113549..1114358 + 810 WP_001289493.1 MBL fold metallo-hydrolase -
spnnt_RS05510 1114449..1114691 + 243 WP_000208080.1 hypothetical protein Antitoxin
spnnt_RS05515 1114693..1114947 + 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
spnnt_RS05520 1114994..1115770 + 777 WP_016398713.1 ion transporter -
spnnt_RS05525 1116026..1117012 - 987 WP_000204727.1 L-lactate dehydrogenase -
spnnt_RS05530 1117206..1119674 + 2469 WP_001153002.1 DNA gyrase subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T46685 WP_001809704.1 NZ_CP007593:1114693-1114947 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T46685 NZ_CP007593:1114693-1114947 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT46685 WP_000208080.1 NZ_CP007593:1114449-1114691 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT46685 NZ_CP007593:1114449-1114691 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References