Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RelB(antitoxin) |
Location | 683498..684143 | Replicon | chromosome |
Accession | NZ_CP007593 | ||
Organism | Streptococcus pneumoniae strain NT_110_58 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A098ZMT4 |
Locus tag | spnnt_RS03240 | Protein ID | WP_016399287.1 |
Coordinates | 683498..683866 (-) | Length | 123 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A098ZEL1 |
Locus tag | spnnt_RS03245 | Protein ID | WP_016399286.1 |
Coordinates | 683856..684143 (-) | Length | 96 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
spnnt_RS03225 | 678905..680521 | + | 1617 | WP_016399136.1 | recombinase family protein | - |
spnnt_RS03230 | 680514..681953 | + | 1440 | WP_016399137.1 | recombinase family protein | - |
spnnt_RS03235 | 682057..683400 | + | 1344 | WP_128972721.1 | DUF1542 domain-containing protein | - |
spnnt_RS03240 | 683498..683866 | - | 369 | WP_016399287.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
spnnt_RS03245 | 683856..684143 | - | 288 | WP_016399286.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
spnnt_RS03255 | 684628..684933 | + | 306 | Protein_632 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
spnnt_RS03260 | 684930..685214 | + | 285 | Protein_633 | type II toxin-antitoxin system RelE/ParE family toxin | - |
spnnt_RS13765 | 685595..685669 | - | 75 | Protein_634 | UDP-galactopyranose mutase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 123 a.a. Molecular weight: 14523.68 Da Isoelectric Point: 9.1169
>T46683 WP_016399287.1 NZ_CP007593:c683866-683498 [Streptococcus pneumoniae]
MDYKVGFTEQARQDLDDIFIYYSTEFSENIAKKVITRLQQITNLLTFSPEGGINFDHKIGYSLYPGNTLRMIVSKQYLLF
YLIHKKEVHILRIINSRTDYLNQLDHLFRNRPITKYIEKSPD
MDYKVGFTEQARQDLDDIFIYYSTEFSENIAKKVITRLQQITNLLTFSPEGGINFDHKIGYSLYPGNTLRMIVSKQYLLF
YLIHKKEVHILRIINSRTDYLNQLDHLFRNRPITKYIEKSPD
Download Length: 369 bp
>T46683 NZ_CP007593:c683866-683498 [Streptococcus pneumoniae]
ATGGACTATAAAGTAGGCTTCACAGAACAAGCCAGACAAGACTTGGACGATATTTTCATCTACTACTCCACAGAGTTCAG
TGAAAACATAGCCAAGAAAGTCATCACTCGCCTCCAACAAATTACCAACCTACTCACCTTCTCACCAGAGGGCGGTATTA
ACTTTGACCATAAAATCGGATACTCCCTCTATCCAGGAAACACTCTCAGAATGATTGTCTCTAAACAATACCTACTCTTT
TACCTCATTCACAAAAAAGAAGTCCATATCCTGAGAATTATCAACTCACGCACCGACTACCTAAACCAACTCGACCACCT
CTTTCGTAACCGTCCAATAACGAAATATATTGAAAAATCTCCAGACTAG
ATGGACTATAAAGTAGGCTTCACAGAACAAGCCAGACAAGACTTGGACGATATTTTCATCTACTACTCCACAGAGTTCAG
TGAAAACATAGCCAAGAAAGTCATCACTCGCCTCCAACAAATTACCAACCTACTCACCTTCTCACCAGAGGGCGGTATTA
ACTTTGACCATAAAATCGGATACTCCCTCTATCCAGGAAACACTCTCAGAATGATTGTCTCTAAACAATACCTACTCTTT
TACCTCATTCACAAAAAAGAAGTCCATATCCTGAGAATTATCAACTCACGCACCGACTACCTAAACCAACTCGACCACCT
CTTTCGTAACCGTCCAATAACGAAATATATTGAAAAATCTCCAGACTAG
Antitoxin
Download Length: 96 a.a. Molecular weight: 10861.36 Da Isoelectric Point: 4.3030
>AT46683 WP_016399286.1 NZ_CP007593:c684143-683856 [Streptococcus pneumoniae]
MSTLTRDRVYNFRVNTQLFEEAKTILESKNISLSDALNLFVEQIVLEKGLPIKTADQLKAEVFLGELKAELDKGYQDIIE
GRLYDADEVFSQYGL
MSTLTRDRVYNFRVNTQLFEEAKTILESKNISLSDALNLFVEQIVLEKGLPIKTADQLKAEVFLGELKAELDKGYQDIIE
GRLYDADEVFSQYGL
Download Length: 288 bp
>AT46683 NZ_CP007593:c684143-683856 [Streptococcus pneumoniae]
ATGTCAACACTTACACGAGACCGAGTTTATAACTTCCGCGTCAATACTCAACTATTTGAAGAAGCAAAAACCATCCTAGA
AAGCAAAAACATCAGCCTTTCAGATGCCCTCAACCTCTTTGTAGAACAAATCGTCCTTGAAAAAGGTCTCCCAATTAAAA
CAGCTGACCAACTAAAAGCAGAAGTCTTCCTAGGCGAACTTAAAGCAGAACTAGATAAAGGCTACCAAGACATCATCGAG
GGGCGTCTCTACGACGCAGACGAGGTCTTTTCACAGTATGGACTATAA
ATGTCAACACTTACACGAGACCGAGTTTATAACTTCCGCGTCAATACTCAACTATTTGAAGAAGCAAAAACCATCCTAGA
AAGCAAAAACATCAGCCTTTCAGATGCCCTCAACCTCTTTGTAGAACAAATCGTCCTTGAAAAAGGTCTCCCAATTAAAA
CAGCTGACCAACTAAAAGCAGAAGTCTTCCTAGGCGAACTTAAAGCAGAACTAGATAAAGGCTACCAAGACATCATCGAG
GGGCGTCTCTACGACGCAGACGAGGTCTTTTCACAGTATGGACTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A098ZMT4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A098ZEL1 |