Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelB(antitoxin)
Location 683498..684143 Replicon chromosome
Accession NZ_CP007593
Organism Streptococcus pneumoniae strain NT_110_58

Toxin (Protein)


Gene name relE Uniprot ID A0A098ZMT4
Locus tag spnnt_RS03240 Protein ID WP_016399287.1
Coordinates 683498..683866 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A098ZEL1
Locus tag spnnt_RS03245 Protein ID WP_016399286.1
Coordinates 683856..684143 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
spnnt_RS03225 678905..680521 + 1617 WP_016399136.1 recombinase family protein -
spnnt_RS03230 680514..681953 + 1440 WP_016399137.1 recombinase family protein -
spnnt_RS03235 682057..683400 + 1344 WP_128972721.1 DUF1542 domain-containing protein -
spnnt_RS03240 683498..683866 - 369 WP_016399287.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
spnnt_RS03245 683856..684143 - 288 WP_016399286.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
spnnt_RS03255 684628..684933 + 306 Protein_632 type II toxin-antitoxin system RelB/DinJ family antitoxin -
spnnt_RS03260 684930..685214 + 285 Protein_633 type II toxin-antitoxin system RelE/ParE family toxin -
spnnt_RS13765 685595..685669 - 75 Protein_634 UDP-galactopyranose mutase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-100)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(11-55)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 14523.68 Da        Isoelectric Point: 9.1169

>T46683 WP_016399287.1 NZ_CP007593:c683866-683498 [Streptococcus pneumoniae]
MDYKVGFTEQARQDLDDIFIYYSTEFSENIAKKVITRLQQITNLLTFSPEGGINFDHKIGYSLYPGNTLRMIVSKQYLLF
YLIHKKEVHILRIINSRTDYLNQLDHLFRNRPITKYIEKSPD

Download         Length: 369 bp

>T46683 NZ_CP007593:c683866-683498 [Streptococcus pneumoniae]
ATGGACTATAAAGTAGGCTTCACAGAACAAGCCAGACAAGACTTGGACGATATTTTCATCTACTACTCCACAGAGTTCAG
TGAAAACATAGCCAAGAAAGTCATCACTCGCCTCCAACAAATTACCAACCTACTCACCTTCTCACCAGAGGGCGGTATTA
ACTTTGACCATAAAATCGGATACTCCCTCTATCCAGGAAACACTCTCAGAATGATTGTCTCTAAACAATACCTACTCTTT
TACCTCATTCACAAAAAAGAAGTCCATATCCTGAGAATTATCAACTCACGCACCGACTACCTAAACCAACTCGACCACCT
CTTTCGTAACCGTCCAATAACGAAATATATTGAAAAATCTCCAGACTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10861.36 Da        Isoelectric Point: 4.3030

>AT46683 WP_016399286.1 NZ_CP007593:c684143-683856 [Streptococcus pneumoniae]
MSTLTRDRVYNFRVNTQLFEEAKTILESKNISLSDALNLFVEQIVLEKGLPIKTADQLKAEVFLGELKAELDKGYQDIIE
GRLYDADEVFSQYGL

Download         Length: 288 bp

>AT46683 NZ_CP007593:c684143-683856 [Streptococcus pneumoniae]
ATGTCAACACTTACACGAGACCGAGTTTATAACTTCCGCGTCAATACTCAACTATTTGAAGAAGCAAAAACCATCCTAGA
AAGCAAAAACATCAGCCTTTCAGATGCCCTCAACCTCTTTGTAGAACAAATCGTCCTTGAAAAAGGTCTCCCAATTAAAA
CAGCTGACCAACTAAAAGCAGAAGTCTTCCTAGGCGAACTTAAAGCAGAACTAGATAAAGGCTACCAAGACATCATCGAG
GGGCGTCTCTACGACGCAGACGAGGTCTTTTCACAGTATGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A098ZMT4

Antitoxin

Source ID Structure
AlphaFold DB A0A098ZEL1

References