46681

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 620753..622185 Replicon chromosome
Accession NZ_CP007593
Organism Streptococcus pneumoniae strain NT_110_58

Toxin (Protein)


Gene name abiEi Uniprot ID A0A064BZ56
Locus tag spnnt_RS03055 Protein ID WP_016569731.1
Coordinates 620753..621598 (-) Length 282 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID A0A064BX97
Locus tag spnnt_RS03060 Protein ID WP_016569730.1
Coordinates 621595..622185 (-) Length 197 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
spnnt_RS03050 618481..620403 + 1923 WP_016399336.1 group II intron reverse transcriptase/maturase -
spnnt_RS03055 620753..621598 - 846 WP_016569731.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
spnnt_RS03060 621595..622185 - 591 WP_016569730.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-266)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(7-51)


Sequences

Toxin        


Download         Length: 282 a.a.        Molecular weight: 32586.12 Da        Isoelectric Point: 5.0402

>T46681 WP_016569731.1 NZ_CP007593:c621598-620753 [Streptococcus pneumoniae]
MNKAKLTALCHNISKQTGLTFNSVMTYYFLEVILKKLSRSSYADHYIFKGGFLLSNIIGVESRSTVDIDFLFHKQTLSEE
NVQQQLEEILSEVKNDIQFSIQSITTIKESDDYGGYRATILCQLENIKQIIHLDIATGDVVTPQPITYDYKAIFNDENFP
IIAYTIETVLAEKLQTIYSRSFLNSRSKDFYDIYILSKLKKDDIDLAQLKMACEKTFSYRETELNFNNIIQLLETFKSDS
TQQQQWQNYSKKYSYTKGISFSEILDEMIRLVSLLISLNNE

Download         Length: 846 bp

>T46681 NZ_CP007593:c621598-620753 [Streptococcus pneumoniae]
ATGAATAAAGCAAAATTAACAGCACTCTGCCATAACATTTCTAAACAGACCGGCCTAACTTTTAACTCAGTAATGACCTA
CTACTTTCTTGAAGTCATTTTGAAAAAGCTAAGTCGAAGTTCTTATGCAGACCATTATATTTTTAAGGGAGGATTTTTGC
TTTCAAATATCATAGGAGTTGAATCTCGTAGCACGGTGGATATTGATTTTCTCTTTCATAAACAAACACTATCAGAAGAA
AATGTTCAACAACAACTGGAAGAAATTTTAAGTGAAGTAAAAAACGATATTCAATTTTCAATTCAATCCATTACAACGAT
TAAAGAAAGCGATGATTACGGTGGTTACCGAGCAACCATTTTGTGTCAACTGGAAAACATTAAACAAATTATCCATTTAG
ATATTGCGACTGGAGATGTTGTTACACCTCAGCCCATTACCTACGATTACAAAGCTATTTTTAATGATGAGAATTTCCCC
ATCATTGCTTATACAATTGAAACGGTGCTAGCTGAAAAATTACAAACCATTTACTCAAGGAGCTTCTTAAACAGTCGTAG
CAAAGATTTTTACGATATCTATATCCTTTCAAAGTTAAAGAAAGACGACATTGATTTGGCACAATTAAAGATGGCTTGTG
AAAAAACCTTCTCTTATCGTGAAACTGAACTCAATTTTAATAACATCATTCAACTGCTTGAAACCTTCAAATCTGACTCT
ACTCAGCAGCAACAATGGCAAAATTATTCAAAAAAATATAGTTATACAAAAGGGATTTCCTTTTCAGAAATCCTTGATGA
GATGATTCGTTTAGTCAGTCTTTTAATCTCTTTAAACAATGAATAA

Antitoxin


Download         Length: 197 a.a.        Molecular weight: 23117.42 Da        Isoelectric Point: 7.1276

>AT46681 WP_016569730.1 NZ_CP007593:c622185-621595 [Streptococcus pneumoniae]
MSKKELLLEYINNHNGLITHRDCKKLGIPTIYLTRLEDEGVIFRVEKGIYLSSSGDYDEYYFFQYRYPRTVFSYISSLYL
QGLTDEIPQYFEVTVPKDYRFRNRPLNLNSYTVSKDIINMGVTSVKTPMGNTVNVYNFERVLCDFILNRSNIDNELFVKT
VQTYSNFPEKNLAKLYDYAQKLNILDDVKRTLEVLL

Download         Length: 591 bp

>AT46681 NZ_CP007593:c622185-621595 [Streptococcus pneumoniae]
ATGTCTAAAAAAGAATTGTTACTTGAGTACATAAACAATCACAATGGTCTGATTACCCATAGAGATTGTAAAAAATTAGG
TATTCCAACCATCTATCTAACGAGACTAGAAGACGAAGGAGTTATCTTTAGGGTCGAAAAAGGTATCTATCTATCTTCTA
GTGGAGATTATGATGAATACTATTTCTTCCAATATCGTTATCCTAGAACTGTCTTTTCTTATATCTCTTCTCTTTATCTA
CAGGGACTTACTGATGAAATTCCTCAATATTTTGAAGTAACAGTTCCCAAGGACTATCGTTTTAGAAACAGACCATTGAA
TCTAAATAGCTACACTGTTTCTAAAGATATTATTAACATGGGGGTTACCAGTGTCAAAACACCTATGGGAAATACGGTTA
ACGTTTATAATTTTGAACGTGTACTATGCGATTTTATCCTTAATCGAAGTAACATTGATAATGAGCTCTTTGTTAAAACA
GTTCAAACTTATAGTAACTTCCCTGAAAAAAATCTTGCAAAACTTTATGACTATGCTCAAAAATTAAATATCTTAGATGA
TGTTAAACGAACCTTGGAGGTACTCTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A064BZ56

Antitoxin

Source ID Structure
AlphaFold DB A0A064BX97

References