Detailed information of TA system TA046655

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 917530..919027
• Replicon: chromosome
• Accession: NZ_CP007590
• Organism: Mycoplasmopsis bovis strain HB0801-P150

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: A0A2N8U3K6
• Locus tag: BC94_RS03925
• Protein ID: WP_014829995.1
• Coordinates: 917530..918390 (-)
• Length: 287 a.a.

Antitoxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: BC94_RS03930
• Protein ID: WP_268872799.1
• Coordinates: 918383..919027 (-)
• Length: 215 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BC94_RS04585 (BC94_0707)	913195..913821	-	627	WP_062931881.1	variable surface lipoprotein	-
BC94_RS04590	913980..914876	-	897	WP_014829992.1	variable surface lipoprotein	-
BC94_RS03915	915575..916534	+	960	WP_062931882.1	variable surface lipoprotein	-
BC94_RS03920	916577..917410	-	834	WP_014829994.1	variable surface lipoprotein	-
BC94_RS03925 (BC94_0716)	917530..918390	-	861	WP_014829995.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
BC94_RS03930 (BC94_0718)	918383..919027	-	645	WP_268872799.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
BC94_RS03935 (BC94_0719)	919408..920157	+	750	WP_013456123.1	tyrosine-type recombinase/integrase	-
BC94_RS03945 (BC94_0720)	920556..922400	+	1845	WP_013955063.1	ribonuclease J	-
BC94_RS03950 (BC94_0721)	922535..923686	+	1152	WP_013955064.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-234)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (23-69)

Sequences

Toxin

Protein

• Length: 287 a.a.
• Molecular weight: 33280.36 Da
• Isoelectric Point: 7.7731

>T46655 WP_014829995.1 NZ_CP007590:c918390-917530 [Mycoplasmopsis bovis]
MNKNKLISLCHKTADQNNANFNVVLIQYFMESILRRISKSNERDNFVFKGGFLLSNIMGLDKRATMDIDLELIKTQKISA
SKILEKFKSILNADDIDGIRYHILKYTDIRKEHKYSGINISVLCQIENIKQVISIDIASGDVITPKEIVYEYKSIFSNQD
FSILAYNIETMLSEKLETIFSFGHLNTRFKDFYDVYVIYTFKKKDIDINRLKDACYNTFKNRNSEFNIQQLLELITNIAF
NPLMNERKKYISQIANQQEIDFKAITNSIIELLELIKVNELTNND

Nucleotide

• Length: 861 bp

>T46655 NZ_CP007590:c918390-917530 [Mycoplasmopsis bovis]
ATGAATAAAAATAAATTAATAAGTTTGTGTCATAAAACTGCTGATCAAAATAACGCAAATTTCAATGTTGTTTTAATTCA
ATATTTTATGGAAAGCATTCTACGAAGAATATCTAAAAGTAATGAGAGAGACAATTTTGTGTTCAAGGGCGGTTTTCTTT
TATCTAACATTATGGGGTTAGATAAAAGAGCTACAATGGATATTGATTTGGAGCTAATAAAAACTCAAAAGATAAGTGCT
TCTAAAATATTAGAAAAATTTAAAAGTATATTAAACGCTGATGACATCGATGGAATTAGATATCACATTCTTAAGTATAC
TGACATTCGAAAGGAGCATAAATATAGTGGCATTAACATATCAGTCCTATGTCAAATAGAGAATATAAAACAAGTTATTT
CTATAGATATTGCATCAGGCGATGTCATTACACCTAAGGAAATTGTTTATGAATACAAAAGTATATTTTCAAATCAGGAT
TTTTCTATTTTAGCTTATAACATTGAAACTATGCTATCTGAAAAGCTTGAGACAATATTTTCTTTTGGTCACTTAAATAC
AAGATTTAAAGATTTTTATGATGTTTATGTTATATACACTTTTAAAAAGAAGGACATTGATATTAATAGGCTCAAGGATG
CTTGCTATAACACATTCAAAAATAGGAACAGTGAATTTAACATACAACAATTGTTGGAACTAATTACCAATATTGCTTTC
AATCCGTTGATGAATGAAAGATGAAAAAAGTACATAAGTCAGATAGCAAATCAGCAGGAAATAGACTTTAAAGCCATTAC
TAATTCAATAATAGAACTACTAGAACTAATTAAGGTCAATGAATTAACAAATAATGATTAA

Antitoxin

Protein

• Length: 215 a.a.
• Molecular weight: 25223.08 Da
• Isoelectric Point: 9.8345

>AT46655 WP_268872799.1 NZ_CP007590:c919027-918383 [Mycoplasmopsis bovis]
VLKYLYNISTNGTKNLNSKYYNAIFKLLHKNNGVITYKQLKENNISSIYLTRMITKGVLIRRAKGIYILSDGHYDEYYFL
SKNYKSLIFSHYSALYLNNIIDIFPHQIDVTVYSGYNAKGIKKHANVYYCDRNKHSIGLSESKTLFGNKVKVYDFERTIC
DFVKLRKKTDSEIFSKLISAYIKYENRDKKLYEYAYELGIHKKISEIFELFYE

Nucleotide

• Length: 645 bp

>AT46655 NZ_CP007590:c919027-918383 [Mycoplasmopsis bovis]
GTGCTTAAATACTTGTATAATATAAGCACAAATGGAACAAAAAACTTAAATTCGAAATATTACAATGCAATTTTTAAACT
GTTACATAAAAATAACGGTGTTATCACATATAAGCAACTAAAAGAAAACAATATATCTTCTATATATTTAACAAGAATGA
TAACAAAAGGCGTTCTTATTAGAAGAGCTAAAGGCATTTATATTCTTAGTGATGGACATTACGATGAATATTATTTCTTA
AGCAAAAACTATAAATCGTTAATCTTTTCTCATTATAGTGCACTATATTTAAATAATATTATTGACATTTTTCCGCATCA
AATTGACGTTACAGTTTACAGTGGCTATAATGCAAAAGGCATTAAGAAGCATGCAAATGTTTACTACTGTGATAGGAATA
AACATTCAATTGGACTATCTGAATCAAAAACATTATTTGGAAACAAAGTTAAGGTATATGACTTTGAGAGAACAATTTGT
GATTTTGTAAAACTACGCAAGAAAACAGATAGCGAAATCTTTTCTAAGCTTATTAGTGCATATATTAAATATGAAAATAG
AGATTGAAAAAAATTGTATGAATACGCCTATGAATTAGGCATACACAAAAAAATATCGGAGATATTTGAACTATTTTATG
AATAA

Structures

Toxin

• AlphaFold DB: A0A2N8U3K6